ENSMUSG00000022665


Mus musculus

Features
Gene ID: ENSMUSG00000022665
  
Biological name :Ccdc80
  
Synonyms : Ccdc80 / Coiled-coil domain-containing protein 80 / Q8R2G6
  
Possible biological names infered from orthology : coiled-coil domain containing 80 / Q76M96
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B5
Gene start: 45093402
Gene end: 45127924
  
Corresponding Affymetrix probe sets: 10435948 (MoGene1.0st)   1424186_at (Mouse Genome 430 2.0 Array)   1424187_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058752
Ensembl peptide - ENSMUSP00000097097
NCBI entrez gene - 67896     See in Manteia.
MGI - MGI:1915146
RefSeq - XM_006522501
RefSeq - NM_026439
RefSeq - XM_006522499
RefSeq - XM_006522500
RefSeq - XM_006522498
RefSeq Peptide - NP_080715
swissprot - Q8R2G6
Ensembl - ENSMUSG00000022665
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccdc80ENSDARG00000000002Danio rerio
 ccdc80l1ENSDARG00000030975Danio rerio
 CCDC80ENSGALG00000015193Gallus gallus
 CCDC80ENSG00000091986Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srpx2 / Q8R054 / Sushi repeat-containing protein SRPX2 / O60687* / sushi repeat containing protein, X-linked 2*ENSMUSG000000312539
Srpx / Q9R0M3 / Sushi-repeat-containing protein SRPX / P78539* / sushi repeat containing protein, X-linked*ENSMUSG000000900849


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR025232  Domain of unknown function DUF4174


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0030198 extracellular matrix organization IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005614 interstitial matrix IDA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0001968 fibronectin binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IDA
 molecular_functionGO:0008201 heparin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
Show

Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0003496 thyroid adenoma "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0003579 ovarian carcinoma 
Show

Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0012436 increased colon tumor incidence "greater than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith]
Show

Allelic Composition: ApcMin/Apc+,Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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