ENSMUSG00000090550


Mus musculus

Features
Gene ID: ENSMUSG00000090550
  
Biological name :Prlh
  
Synonyms : Prlh / prolactin releasing hormone
  
Possible biological names infered from orthology : P81277
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 90953108
Gene end: 90954027
  
Corresponding Affymetrix probe sets: 10348489 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000130768
NCBI entrez gene - 623503     See in Manteia.
MGI - MGI:3644668
RefSeq - NM_001101647
RefSeq - XM_006529772
RefSeq Peptide - NP_001095117
swissprot - G3UWC3
Ensembl - ENSMUSG00000090550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prlh2ENSDARG00000071735Danio rerio
 PRLHENSGALG00000040716Gallus gallus
 PRLHENSG00000071677Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026194  Prolactin-releasing peptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0002021 response to dietary excess IMP
 biological_processGO:0002023 reduction of food intake in response to dietary excess ISO
 biological_processGO:0006112 energy reserve metabolic process IMP
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042755 eating behavior IMP
 biological_processGO:0043434 response to peptide hormone IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0048483 autonomic nervous system development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA
 molecular_functionGO:0031861 prolactin-releasing peptide receptor binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln,7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln,7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006276 abnormal autonomic nervous system physiology "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009288 increased epididymal fat pad weight 
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prlhtm2Smln/Prlhtm2Smln
Genetic Background: involves: C57BL/6J

 MP:0011958 increased compensatory feeding amount "increased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045052 Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*  / reaction / complex






 

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