ENSMUSG00000045052


Mus musculus

Features
Gene ID: ENSMUSG00000045052
  
Biological name :Prlhr
  
Synonyms : Prlhr / Prolactin-releasing peptide receptor / Q6VMN6
  
Possible biological names infered from orthology : P49683 / prolactin releasing hormone receptor
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: D3
Gene start: 60466733
Gene end: 60468304
  
Corresponding Affymetrix probe sets: 10468810 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000063114
NCBI entrez gene - 226278     See in Manteia.
MGI - MGI:2135956
RefSeq - NM_201615
RefSeq - XM_006527057
RefSeq Peptide - NP_963909
swissprot - Q6VMN6
Ensembl - ENSMUSG00000045052
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prlhr2aENSDARG00000044900Danio rerio
 prlhr2bENSDARG00000036458Danio rerio
 PRLHRENSGALG00000020656Gallus gallus
 PRLHRLENSGALG00000003142Gallus gallus
 PRLHRENSG00000119973Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*ENSMUSG0000002800430
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193230
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*ENSMUSG0000004833730
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*ENSMUSG0000004401429
Pgr15lENSMUSG0000003121227
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643727
Tacr1 / P30548 / tachykinin receptor 1 / P25103*ENSMUSG0000003004326
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*ENSMUSG0000004940925
Npy6r / Q61212 / Neuropeptide Y receptor type 6 ENSMUSG0000003807125
Tacr3 / P47937 / tachykinin receptor 3 / P29371*ENSMUSG0000002817225
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008124
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*ENSMUSG0000005055824
Gpr165ENSMUSG0000003121023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001402  Prolactin-releasing peptide receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007631 feeding behavior IMP
 biological_processGO:0042445 hormone metabolic process IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IDA
 molecular_functionGO:0004983 neuropeptide Y receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001981 enhanced chemically-elicited antinociception "greater than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0009713 enhanced conditioned place preference behavior "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009776 decreased behavioral withdrawal response "decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000090550 Prlh / prolactin releasing hormone / P81277*  / reaction / complex






 

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