Manteia - Molecule gene

ENSMUSG00000036437

Mus musculus

Features

Gene ID:	ENSMUSG00000036437

Biological name :	Npy1r

Synonyms :	Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / Npy1r / Q04573

Possible biological names infered from orthology :	neuropeptide Y receptor Y1 / P25929

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	B3.1
Gene start:	66697192
Gene end:	66706792

Corresponding Affymetrix probe sets:	10572070 (MoGene1.0st) 1421471_at (Mouse Genome 430 2.0 Array) 1426054_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000045530 Ensembl peptide - ENSMUSP00000148417 NCBI entrez gene - 18166 See in Manteia. MGI - MGI:104963 RefSeq - XM_017312614 RefSeq - NM_001358955 RefSeq - NM_010934 RefSeq - XM_006509594 RefSeq - XM_006509595 RefSeq - XM_006509596 RefSeq Peptide - NP_001345884 RefSeq Peptide - NP_035064 swissprot - Q04573 swissprot - Q3V1K5 Ensembl - ENSMUSG00000036437

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
npy1r	ENSDARG00000037411	Danio rerio
NPY1R	ENSGALG00000009498	Gallus gallus
NPY1R	ENSG00000164128	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Npy6r / Q61212 / Neuropeptide Y receptor type 6	ENSMUSG00000038071	50
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*	ENSMUSG00000048337	45
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*	ENSMUSG00000044014	30
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*	ENSMUSG00000031932	27
Tacr3 / P47937 / tachykinin receptor 3 / P29371*	ENSMUSG00000028172	26
Tacr2 / P30549 / tachykinin receptor 2 / P21452*	ENSMUSG00000020081	26
Tacr1 / P30548 / tachykinin receptor 1 / P25103*	ENSMUSG00000030043	26
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*	ENSMUSG00000028004	26
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*	ENSMUSG00000045052	26
Pgr15l	ENSMUSG00000031212	25
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*	ENSMUSG00000049409	23
Gpr165	ENSMUSG00000031210	23
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*	ENSMUSG00000050558	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR000351	Neuropeptide Y1 receptor
IPR000611	Neuropeptide Y receptor family
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003151	outflow tract morphogenesis	IEA
biological_process	GO:0006006	glucose metabolic process	IMP
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007218	neuropeptide signaling pathway	IEA
biological_process	GO:0007268	chemical synaptic transmission	IBA
biological_process	GO:0007626	locomotory behavior	IMP
biological_process	GO:0007631	feeding behavior	IMP
biological_process	GO:0008217	regulation of blood pressure	IMP
biological_process	GO:0019233	sensory perception of pain	IMP
biological_process	GO:0040014	regulation of multicellular organism growth	IMP
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0001601	peptide YY receptor activity	IDA
molecular_function	GO:0001602	pancreatic polypeptide receptor activity	IDA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004983	neuropeptide Y receptor activity	IDA

Pathways (from Reactome)

Pathway description

Peptide ligand-binding receptors

G alpha (i) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000008	increased white fat amount	"increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax5^m1Anu/Pax5^m1Anu Genetic Background: C57BL/6JAnu-Pax5^m1Anu
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Wnt11^tm1.1Khay/Wnt11^tm1.2Khay,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0000250	abnormal vasoconstriction	"anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001007	abnormal sympathetic system morphology	"malformation of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Fermt2^{Gt(AM0293)Wtsi}/Fermt2^{Gt(AM0293)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped Allelic Composition: Npy1r^tm1Aka/Npy1r^tm1Aka Genetic Background: involves: C57BL/6 * CBA
MP:0001353	increased aggression to other mice	"when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001363	increased anxiety-related response	"when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]	Show Allelic Composition: Tnfsf11^tles/Tnfsf11^tm1Pngr Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv Allelic Composition: Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001431	abnormal eating behavior	"inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]	Show Allelic Composition: Gabra2^tm1Dias/Gabra2^tm1Dias Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gphn^tm1Jrs/Gphn^tm1Jrs Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001745	increased circulating corticosterone level	"greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped Allelic Composition: Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001819	abnormal immune cell physiology	"abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001845	abnormal inflammatory response	"aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001934	increased litter size	"greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gphn^tm1Jrs/Gphn^tm1Jrs Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped Allelic Composition: Npy1r^tm1Mnak/Npy1r^tm1Mnak Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002452	abnormal antigen presenting cell physiology	"impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002495	increased IgA	"greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002862	altered righting response	"altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Npy1r^tm1Pern/Npy1r^tm1Pern,Npy2r^tm1Pern/Npy2r^tm1Pern Genetic Background: involves: 129/Sv Allelic Composition: Npy1r^tm1Pern/Npy1r^tm1Pern Genetic Background: Not Specified
MP:0003545	increased alcohol consumption	"greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0004149	increased bone strength	"increased ability of bone to endure the application of force without yielding or breaking" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt11^tm1.1Khay/Wnt11^tm1.2Khay,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0004275	abnormal postnatal subventricular zone morphology	"any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Per1^tm1Brd/Per1^tm1Brd,Per2^tm1Brd/Per2^tm1.1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: 129S7/SvEvBrd * FVB
MP:0004279	abnormal rostral migratory stream morphology	"any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Per1^tm1Brd/Per1^tm1Brd,Per2^tm1Brd/Per2^tm1.1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: 129S7/SvEvBrd * FVB
MP:0004889	increased energy expenditure	"increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0004890	decreased energy expenditure	"decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1Mnak/Npy1r^tm1Mnak Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004981	decreased neuronal precursor cell number	"reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Per1^tm1Brd/Per1^tm1Brd,Per2^tm1Brd/Per2^tm1.1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: 129S7/SvEvBrd * FVB
MP:0005006	abnormal osteoblast function	"anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wnt11^tm1.1Khay/Wnt11^tm1.2Khay,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005290	decreased oxygen consumption	"less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npy1r^tm1Mnak/Npy1r^tm1Mnak Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0005437	abnormal glycogen level	"anomalous concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0005450	abnormal energy expenditure	"utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv
MP:0005458	increased percent body fat	"more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0005465	abnormal T helper 1 physiology	"anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0005608	cardiac interstitial fibrosis	"formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0005616	decreased susceptibility to type IV hypersensitivity reaction	"less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0006092	abnormal olfactory neuron morphology	"malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]	Show Allelic Composition: Per1^tm1Brd/Per1^tm1Brd,Per2^tm1Brd/Per2^tm1.1Kry,Tg(Col1a1-cre)1Kry/0 Genetic Background: involves: 129S7/SvEvBrd * FVB
MP:0006387	abnormal T cell number	"deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008082	increased single-positive T cell number	"greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008158	increased diameter of femur	"increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt11^tm1.1Khay/Wnt11^tm1.2Khay,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0008182	decreased marginal zone B cell number	"reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008190	decreased transitional stage B cell number	"reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Wnt11^tm1.1Khay/Wnt11^tm1.2Khay,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL
MP:0008496	decreased IgG2a level	"less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008501	increased IgG2b level	"greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008554	decreased circulating tumor necrosis factor level	"reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008618	decreased circulating interleukin-12 level	"reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008826	abnormal splenic cell ratio	"deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008828	abnormal lymph node cell ratio	"deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL
MP:0008907	decreased total fat pad weight	"less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL
MP:0009285	increased gonadal fat pad weight	"greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1Mnak/Npy1r^tm1Mnak Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009288	increased epididymal fat pad weight		Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0009289	decreased epididymal fat pad weight		Show Allelic Composition: Npy1r^tm1.1Ceva/Npy1r^tm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL
MP:0009304	increased retroperitoneal fat pad weight		Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped Allelic Composition: Npy1r^tm1Mnak/Npy1r^tm1Mnak Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009347	increased cancellous bone thickness	"thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt11^tm1.1Khay/Wnt11^tm1.2Khay,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0009755	impaired behavioral response to alcohol	"decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0009767	decreased sensitivity to xenobiotic induced morbidity/mortality	"increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex,Plscr3^tm1Sims/Plscr3^tm1Sims Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt11^tm1.1Khay/Wnt11^tm1.2Khay,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0010182	decreased susceptibility to weight gain	"smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0010378	increased respiratory quotient	"increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt11^tm1.1Khay/Wnt11^tm1.2Khay,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0011957	decreased compensatory feeding amount	"decreased amount of food consumed after a period of fasting" [MGI:csmith]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And Genetic Background: involves: 129/Sv Allelic Composition: Npy1r^tm1Snby/Npy1r^tm1Snby,Npy5r^tm1Snby/Npy5r^tm1Snby Genetic Background: involves: 129 * C57BL/6
MP:0030016	increased adipocyte glucose uptake	"increased ability of adipocytes to take in glucose" [MGI:anna]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000017311	Pyy / Q9EPS2 / peptide YY / P10082*	/ complex / reaction
ENSMUSG00000017316	Ppy / P10601 / pancreatic polypeptide / P01298*	/ complex / reaction
ENSMUSG00000029819	Npy / P57774 / Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY / P01303* / neuropeptide Y*	/ reaction / complex

1 s.

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