ENSMUSG00000028172


Mus musculus

Features
Gene ID: ENSMUSG00000028172
  
Biological name :Tacr3
  
Synonyms : P47937 / tachykinin receptor 3 / Tacr3
  
Possible biological names infered from orthology : P29371
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 134829007
Gene end: 134934579
  
Corresponding Affymetrix probe sets: 10496192 (MoGene1.0st)   1437029_at (Mouse Genome 430 2.0 Array)   1440803_x_at (Mouse Genome 430 2.0 Array)   1450278_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029822
NCBI entrez gene - 21338     See in Manteia.
MGI - MGI:892968
RefSeq - NM_021382
RefSeq Peptide - NP_067357
swissprot - P47937
Ensembl - ENSMUSG00000028172
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO904943.1ENSDARG00000043918Danio rerio
 tacr3aENSDARG00000075112Danio rerio
 tacr3lENSDARG00000003054Danio rerio
 TACR3ENSGALG00000010596Gallus gallus
 TACR3ENSG00000169836Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tacr1 / P30548 / tachykinin receptor 1 / P25103*ENSMUSG0000003004352
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008142
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193225
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643722
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*ENSMUSG0000004833720
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*ENSMUSG0000004505220
Pgr15lENSMUSG0000003121220
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*ENSMUSG0000002800420
Gpr165ENSMUSG0000003121019
Npy6r / Q61212 / Neuropeptide Y receptor type 6 ENSMUSG0000003807119
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*ENSMUSG0000004940918
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*ENSMUSG0000005055818
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*ENSMUSG0000004401417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001013  Neurokinin NK3 receptor
 IPR001681  Neurokinin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007217 tachykinin receptor signaling pathway IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042538 hyperosmotic salinity response IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0060259 regulation of feeding behavior IEA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 biological_processGO:1902093 positive regulation of flagellated sperm motility IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0097225 sperm midpiece IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004995 tachykinin receptor activity IEA


Pathways (from Reactome)
Pathway description
Tachykinin receptors bind tachykinins
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0002798 abnormal active avoidance behavior "defects in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025400 Tac2 / P55099 / Tachykinin-3 Neurokinin-B / TAC3* / Q9UHF0* / tachykinin 3*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr