ENSMUSG00000044014


Mus musculus

Features
Gene ID: ENSMUSG00000044014
  
Biological name :Npy5r
  
Synonyms : Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Npy5r / O70342
  
Possible biological names infered from orthology : neuropeptide Y receptor Y5 / Q15761
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.1
Gene start: 66679965
Gene end: 66688128
  
Corresponding Affymetrix probe sets: 10578973 (MoGene1.0st)   1419008_at (Mouse Genome 430 2.0 Array)   1449312_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065157
Ensembl peptide - ENSMUSP00000148410
Ensembl peptide - ENSMUSP00000148589
NCBI entrez gene - 18168     See in Manteia.
MGI - MGI:108082
RefSeq - XM_006509599
RefSeq - NM_001358957
RefSeq - NM_001358958
RefSeq - NM_016708
RefSeq - XM_006509598
RefSeq Peptide - NP_057917
RefSeq Peptide - NP_001345886
RefSeq Peptide - NP_001345887
swissprot - O70342
swissprot - Q543U8
Ensembl - ENSMUSG00000044014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPY5RENSGALG00000009499Gallus gallus
 NPY5RENSG00000164129Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643724
Npy6r / Q61212 / Neuropeptide Y receptor type 6 ENSMUSG0000003807123
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*ENSMUSG0000004505223
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*ENSMUSG0000004833723
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*ENSMUSG0000002800421
Pgr15lENSMUSG0000003121218
Tacr3 / P47937 / tachykinin receptor 3 / P29371*ENSMUSG0000002817217
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193217
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*ENSMUSG0000004940916
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008116
Tacr1 / P30548 / tachykinin receptor 1 / P25103*ENSMUSG0000003004316
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*ENSMUSG0000005055816
Gpr165ENSMUSG0000003121015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000393  Neuropeptide Y5 receptor
 IPR000611  Neuropeptide Y receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002675 positive regulation of acute inflammatory response IEA
 biological_processGO:0002865 negative regulation of acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0003151 outflow tract morphogenesis ISO
 biological_processGO:0003214 cardiac left ventricle morphogenesis ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0008015 blood circulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0014050 negative regulation of glutamate secretion IEA
 biological_processGO:0032229 negative regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0060112 generation of ovulation cycle rhythm IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0001601 peptide YY receptor activity IDA
 molecular_functionGO:0001602 pancreatic polypeptide receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004983 neuropeptide Y receptor activity IDA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax5m1Anu/Pax5m1Anu
Genetic Background: C57BL/6JAnu-Pax5m1Anu

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

Allelic Composition: Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Pax5m1Anu/Pax5m1Anu
Genetic Background: C57BL/6JAnu-Pax5m1Anu

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

Allelic Composition: Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npy5rtm1Aka/Npy5rtm1Aka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

Allelic Composition: Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
Show

Allelic Composition: Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Npy5rtm1Aka/Npy5rtm1Aka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009304 increased retroperitoneal fat pad weight 
Show

Allelic Composition: Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Npy5rtm1Aka/Npy5rtm1Aka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017311 Pyy / Q9EPS2 / peptide YY / P10082*  / complex / reaction
 ENSMUSG00000017316 Ppy / P10601 / pancreatic polypeptide / P01298*  / complex / reaction
 ENSMUSG00000029819 Npy / P57774 / Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY / P01303* / neuropeptide Y*  / reaction / complex






 

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