ENSMUSG00000017311


Mus musculus

Features
Gene ID: ENSMUSG00000017311
  
Biological name :Pyy
  
Synonyms : peptide YY / Pyy / Q9EPS2
  
Possible biological names infered from orthology : P10082
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 102106676
Gene end: 102107832
  
Corresponding Affymetrix probe sets: 10391561 (MoGene1.0st)   1424865_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017455
Ensembl peptide - ENSMUSP00000134812
Ensembl peptide - ENSMUSP00000135292
NCBI entrez gene - 217212     See in Manteia.
MGI - MGI:99924
RefSeq - XM_006533039
RefSeq - NM_001346771
RefSeq - NM_145435
RefSeq Peptide - NP_001333700
RefSeq Peptide - NP_663410
swissprot - Q3V334
swissprot - Q9EPS2
swissprot - H3BK86
Ensembl - ENSMUSG00000017311
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pyyaENSDARG00000053449Danio rerio
 pyybENSDARG00000035832Danio rerio
 PYYENSG00000131096Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npy / P57774 / Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY / P01303* / neuropeptide Y*ENSMUSG0000002981945


Protein motifs (from Interpro)
Interpro ID Name
 IPR001955  Pancreatic hormone-like
 IPR020392  Pancreatic hormone-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007586 digestion IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032098 regulation of appetite IBA
 biological_processGO:0042755 eating behavior IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IDA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Pyytm1Batt/Pyytm1Batt
Genetic Background: involves: C57BL/6 * SJL

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: KitW/KitW-v
Genetic Background: involves: C57BL/6J

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pyytm1Batt/Pyytm1Batt
Genetic Background: involves: C57BL/6 * SJL

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pyytm1Batt/Pyytm1Batt
Genetic Background: involves: C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pyytm1Batt/Pyytm1Batt
Genetic Background: involves: C57BL/6 * SJL

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pyytm1Mws/Pyytm1Mws
Genetic Background: involves: C57BL/6J

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pyytm1Batt/Pyytm1Batt
Genetic Background: involves: C57BL/6 * SJL

 MP:0003795 abnormal bone structure 
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pyytm1Mws/Pyytm1Mws
Genetic Background: involves: C57BL/6J

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pyytm1Mws/Pyytm1Mws
Genetic Background: involves: C57BL/6J

 MP:0004702 increased circulating insulin-like growth factor I level "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: KitW/KitW-v
Genetic Background: involves: C57BL/6J

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW/KitW-v
Genetic Background: involves: C57BL/6J

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Pyytm1Batt/Pyytm1Batt
Genetic Background: involves: C57BL/6 * SJL

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pyytm1.1Batt/Pyytm1.1Batt
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pyytm1Mws/Pyytm1Mws
Genetic Background: involves: C57BL/6J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000044014 Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*  / complex / reaction
 ENSMUSG00000036437 Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*  / complex / reaction
 ENSMUSG00000028004 Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*  / complex / reaction
 ENSMUSG00000048337 Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*  / reaction / complex






 

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