ENSMUSG00000028004


Mus musculus

Features
Gene ID: ENSMUSG00000028004
  
Biological name :Npy2r
  
Synonyms : Neuropeptide Y receptor type 2 / Npy2r / P97295
  
Possible biological names infered from orthology : neuropeptide Y receptor Y2 / P49146
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 82538383
Gene end: 82548084
  
Corresponding Affymetrix probe sets: 10498965 (MoGene1.0st)   1417489_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029633
Ensembl peptide - ENSMUSP00000096595
Ensembl peptide - ENSMUSP00000138282
Ensembl peptide - ENSMUSP00000138559
NCBI entrez gene - 18167     See in Manteia.
MGI - MGI:108418
RefSeq - XM_006501116
RefSeq - NM_001205099
RefSeq - NM_008731
RefSeq - XM_006501115
RefSeq Peptide - NP_001192028
RefSeq Peptide - NP_032757
swissprot - P97295
swissprot - Q3SWR9
Ensembl - ENSMUSG00000028004
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npy2rENSDARG00000094763Danio rerio
 npy2rlENSDARG00000089943Danio rerio
 NPY2RENSGALG00000009280Gallus gallus
 NPY2RENSG00000185149Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*ENSMUSG0000004505229
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643727
Npy6r / Q61212 / Neuropeptide Y receptor type 6 ENSMUSG0000003807127
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193227
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*ENSMUSG0000004401426
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*ENSMUSG0000004833726
Tacr3 / P47937 / tachykinin receptor 3 / P29371*ENSMUSG0000002817224
Pgr15lENSMUSG0000003121224
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*ENSMUSG0000004940924
Tacr1 / P30548 / tachykinin receptor 1 / P25103*ENSMUSG0000003004323
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008123
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*ENSMUSG0000005055823
Gpr165ENSMUSG0000003121020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000611  Neuropeptide Y receptor family
 IPR001358  Neuropeptide Y2 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0002793 positive regulation of peptide secretion IEA
 biological_processGO:0003151 outflow tract morphogenesis ISO
 biological_processGO:0003214 cardiac left ventricle morphogenesis ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0031645 negative regulation of neurological system process IEA
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA
 biological_processGO:0046903 secretion IEA
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0051048 negative regulation of secretion IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IEA
 biological_processGO:2000252 negative regulation of feeding behavior IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0001601 peptide YY receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004983 neuropeptide Y receptor activity IDA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf2tm1Bee/Fgf2+,Tg(Tyrp1-TAg)3434Bee/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
Show

Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0002570 alcohol aversion 
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlr+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf2tm1Bee/Fgf2+,Tg(Tyrp1-TAg)3434Bee/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Npy1rtm1Pern/Npy1rtm1Pern,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0003795 abnormal bone structure 
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0004702 increased circulating insulin-like growth factor I level "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0005137 increased growth hormone level "greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0008459 abnormal circulating pancreatic peptide level "anomaly in the amount of the 36-amino acid pancreatic hormone in the blood that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D06.472.699.587.700]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009299 decreased mesenteric fat pad weight 
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0011021 abnormal circadian regulation of heart rate "anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours" [GO:0003053]
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011385 abnormal testosterone level "anomaly in the concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/cJ

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0014145 increased white adipose tissue mass "increased physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Npy2rtm1Hhz/Npy2rtm1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017311 Pyy / Q9EPS2 / peptide YY / P10082*  / reaction / complex
 ENSMUSG00000017316 Ppy / P10601 / pancreatic polypeptide / P01298*  / reaction / complex
 ENSMUSG00000029819 Npy / P57774 / Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY / P01303* / neuropeptide Y*  / complex / reaction






 

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