ENSMUSG00000050558


Mus musculus

Features
Gene ID: ENSMUSG00000050558
  
Biological name :Prokr2
  
Synonyms : Prokineticin receptor 2 / Prokr2 / Q8K458
  
Possible biological names infered from orthology : Q8NFJ6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F2
Gene start: 132337733
Gene end: 132385447
  
Corresponding Affymetrix probe sets: 10487937 (MoGene1.0st)   1437695_at (Mouse Genome 430 2.0 Array)   1440564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105784
Ensembl peptide - ENSMUSP00000124526
Ensembl peptide - ENSMUSP00000115564
Ensembl peptide - ENSMUSP00000105785
Ensembl peptide - ENSMUSP00000056659
NCBI entrez gene - 246313     See in Manteia.
MGI - MGI:2181363
RefSeq - XM_011239558
RefSeq - NM_144944
RefSeq - XM_011239555
RefSeq Peptide - NP_659193
swissprot - E0CY28
swissprot - Q8K458
swissprot - A2AMQ7
swissprot - A2AMQ9
Ensembl - ENSMUSG00000050558
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prokr1aENSDARG00000074182Danio rerio
 prokr1bENSDARG00000111213Danio rerio
 PROKR2ENSGALG00000008741Gallus gallus
 PROKR2ENSG00000101292Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*ENSMUSG0000004940981
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*ENSMUSG0000002800423
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*ENSMUSG0000004833723
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*ENSMUSG0000004505223
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008122
Tacr1 / P30548 / tachykinin receptor 1 / P25103*ENSMUSG0000003004322
Tacr3 / P47937 / tachykinin receptor 3 / P29371*ENSMUSG0000002817221
Npy6r / Q61212 / Neuropeptide Y receptor type 6 ENSMUSG0000003807121
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643721
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*ENSMUSG0000004401420
Pgr15lENSMUSG0000003121220
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193219
Gpr165ENSMUSG0000003121017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000611  Neuropeptide Y receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007623 circadian rhythm IDA
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0008015 blood circulation IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001602 pancreatic polypeptide receptor activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0004983 neuropeptide Y receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0004895 vagina atrophy "wasting of the vagina due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000070368 Prok1 / Q14A28 / Prokineticin-1 / P58294*  / complex / reaction
 ENSMUSG00000030069 Prok2 / Q9QXU7 / prokineticin 2 / Q9HC23*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr