ENSMUSG00000049409


Mus musculus

Features
Gene ID: ENSMUSG00000049409
  
Biological name :Prokr1
  
Synonyms : Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Prokr1 / Q9JKL1
  
Possible biological names infered from orthology : prokineticin receptor 1 / Q8TCW9
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 87578591
Gene end: 87590743
  
Corresponding Affymetrix probe sets: 10546024 (MoGene1.0st)   1450279_at (Mouse Genome 430 2.0 Array)   1456543_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059034
Ensembl peptide - ENSMUSP00000144999
Ensembl peptide - ENSMUSP00000145476
NCBI entrez gene - 58182     See in Manteia.
MGI - MGI:1929676
RefSeq - XM_006506433
RefSeq - NM_001355655
RefSeq - NM_021381
RefSeq - XM_006506431
RefSeq - XM_006506432
RefSeq Peptide - NP_001342584
RefSeq Peptide - NP_067356
swissprot - Q9JKL1
swissprot - A0A0N4SWD5
Ensembl - ENSMUSG00000049409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prokr1aENSDARG00000074182Danio rerio
 prokr1bENSDARG00000111213Danio rerio
 PROKR2ENSGALG00000008741Gallus gallus
 PROKR1ENSG00000169618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*ENSMUSG0000005055878
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*ENSMUSG0000004505224
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*ENSMUSG0000002800423
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643722
Npy6r / Q61212 / Neuropeptide Y receptor type 6 ENSMUSG0000003807122
Tacr1 / P30548 / tachykinin receptor 1 / P25103*ENSMUSG0000003004321
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*ENSMUSG0000004833721
Tacr3 / P47937 / tachykinin receptor 3 / P29371*ENSMUSG0000002817221
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008121
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*ENSMUSG0000004401419
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193219
Pgr15lENSMUSG0000003121218
Gpr165ENSMUSG0000003121016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000611  Neuropeptide Y receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0008015 blood circulation IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0060976 coronary vasculature development TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001602 pancreatic polypeptide receptor activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0004983 neuropeptide Y receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ieg

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxn1nu/Foxn1+
Genetic Background: C.Cg-Foxn1nu

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ieg

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu/Foxn1+
Genetic Background: C.Cg-Foxn1nu

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: PhexHyp/Y
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Y
Genetic Background: Not Specified

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Y
Genetic Background: Not Specified

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: PhexHyp/Y
Genetic Background: Not Specified

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

Allelic Composition: Prokr1tm1.1(KOMP)Vlcg/Prokr1+
Genetic Background: C57BL/6N-Prokr1tm1.1(KOMP)Vlcg/Ucd

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PhexHyp/Y
Genetic Background: Not Specified

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PhexHyp/Y
Genetic Background: Not Specified

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: PhexHyp/Y
Genetic Background: Not Specified

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0011947 abnormal fluid intake "significant anomaly in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: PhexHyp/Y
Genetic Background: Not Specified

 MP:0020329 decreased capillary density "reduction in the number of capillaries in a given cross-sectional area of a tissue" [ORCID: orcid.org/0000-0003-4606-0597, PMID:20944627]
Show

Allelic Composition: Foxn1nu/Foxn1+
Genetic Background: C.Cg-Foxn1nu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030069 Prok2 / Q9QXU7 / prokineticin 2 / Q9HC23*  / complex / reaction
 ENSMUSG00000070368 Prok1 / Q14A28 / Prokineticin-1 / P58294*  / reaction / complex






 

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