ENSMUSG00000030069


Mus musculus

Features
Gene ID: ENSMUSG00000030069
  
Biological name :Prok2
  
Synonyms : Prok2 / prokineticin 2 / Q9QXU7
  
Possible biological names infered from orthology : Q9HC23
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D3
Gene start: 99711299
Gene end: 99726392
  
Corresponding Affymetrix probe sets: 10546695 (MoGene1.0st)   1419681_a_at (Mouse Genome 430 2.0 Array)   1426176_a_at (Mouse Genome 430 2.0 Array)   1451952_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008273
Ensembl peptide - ENSMUSP00000032152
Ensembl peptide - ENSMUSP00000098678
Ensembl peptide - ENSMUSP00000144760
NCBI entrez gene - 50501     See in Manteia.
MGI - MGI:1354178
RefSeq - NM_001037539
RefSeq - NM_001170419
RefSeq - NM_015768
RefSeq Peptide - NP_001032628
RefSeq Peptide - NP_001163890
RefSeq Peptide - NP_056583
swissprot - Q9QXU7
swissprot - G3X8R6
swissprot - Q14AB2
Ensembl - ENSMUSG00000030069
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prok2ENSDARG00000091616Danio rerio
 PROK2ENSGALG00000007785Gallus gallus
 PROK2ENSG00000163421Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prok1 / Q14A28 / Prokineticin-1 / P58294*ENSMUSG0000007036835


Protein motifs (from Interpro)
Interpro ID Name
 IPR009523  Prokineticin
 IPR023569  Prokineticin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IBA
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0003349 epicardium-derived cardiac endothelial cell differentiation TAS
 biological_processGO:0006935 chemotaxis ISO
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007623 circadian rhythm IDA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0045765 regulation of angiogenesis IBA
 biological_processGO:0045987 positive regulation of smooth muscle contraction ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0060976 coronary vasculature development TAS
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS
 biological_processGO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation TAS
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding TAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049409 Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*  / complex / reaction
 ENSMUSG00000050558 Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*  / reaction / complex






 

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