ENSMUSG00000030043


Mus musculus

Features
Gene ID: ENSMUSG00000030043
  
Biological name :Tacr1
  
Synonyms : P30548 / tachykinin receptor 1 / Tacr1
  
Possible biological names infered from orthology : P25103
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 82402334
Gene end: 82560104
  
Corresponding Affymetrix probe sets: 10539244 (MoGene1.0st)   1422282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032122
Ensembl peptide - ENSMUSP00000145217
NCBI entrez gene - 21336     See in Manteia.
MGI - MGI:98475
RefSeq - XM_006505865
RefSeq - NM_009313
RefSeq - XM_006505863
RefSeq - XM_006505864
RefSeq Peptide - NP_033339
swissprot - P30548
Ensembl - ENSMUSG00000030043
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tacr1aENSDARG00000035533Danio rerio
 tacr1bENSDARG00000102900Danio rerio
 TACR1ENSGALG00000036638Gallus gallus
 TACR1ENSG00000115353Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tacr3 / P47937 / tachykinin receptor 3 / P29371*ENSMUSG0000002817258
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008146
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193226
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*ENSMUSG0000004505224
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643724
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*ENSMUSG0000002800422
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*ENSMUSG0000004833722
Pgr15lENSMUSG0000003121222
Gpr165ENSMUSG0000003121021
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*ENSMUSG0000005055820
Npy6r / Q61212 / Neuropeptide Y receptor type 6 ENSMUSG0000003807120
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*ENSMUSG0000004940920
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*ENSMUSG0000004401418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000046  Neurokinin NK1 receptor
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001681  Neurokinin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002118 aggressive behavior IEA
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0003051 angiotensin-mediated drinking behavior IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0007217 tachykinin receptor signaling pathway ISO
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010193 response to ozone IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010996 response to auditory stimulus IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014910 regulation of smooth muscle cell migration IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0032224 positive regulation of synaptic transmission, cholinergic IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035106 operant conditioning IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045760 positive regulation of action potential IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IBA
 biological_processGO:0046878 positive regulation of saliva secretion IEA
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0048266 behavioral response to pain IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0060083 smooth muscle contraction involved in micturition IEA
 biological_processGO:0070472 regulation of uterine smooth muscle contraction IDA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 biological_processGO:1902093 positive regulation of flagellated sperm motility ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0036126 sperm flagellum ISO
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0061827 sperm head ISO
 cellular_componentGO:0071944 cell periphery IDA
 cellular_componentGO:0097225 sperm midpiece ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004995 tachykinin receptor activity IEA
 molecular_functionGO:0016496 substance P receptor activity ISO


Pathways (from Reactome)
Pathway description
Tachykinin receptors bind tachykinins
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbn1tm2Rmz/Fbn1tm2Rmz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wrntm1Led/Wrn+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0002735 abnormal chemical nociception "abnormal capability to sense pain elicited by chemical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wrntm1Led/Wrn+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003481 decreased nerve fiber response intensity 
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0003663 abnormal thermosensation "defect in the ability to sense or display a preference for a given temperature" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96549]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0005572 abnormal breathing frequency "deviation from the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Tg(tetO-HIST1H2BJ/GFP)47Efu/?,Waptm2(rtTA)Kuw/Wap+
Genetic Background: involves: 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000061762 Tac1 / P41539 / tachykinin 1 / P20366* / tachykinin precursor 1*  / complex / reaction






 

1 s.

 
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