Manteia

ENSMUSG00000061762

Mus musculus

Features

Gene ID:	ENSMUSG00000061762

Biological name :	Tac1

Synonyms :	P41539 / Tac1 / tachykinin 1

Possible biological names infered from orthology :	P20366 / tachykinin precursor 1

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	A1
Gene start:	7554879
Gene end:	7565834

Corresponding Affymetrix probe sets:	10536363 (MoGene1.0st) 1416783_at (Mouse Genome 430 2.0 Array) 1431883_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000139347 Ensembl peptide - ENSMUSP00000088175 Ensembl peptide - ENSMUSP00000138818 Ensembl peptide - ENSMUSP00000139032 NCBI entrez gene - 21333 See in Manteia. MGI - MGI:98474 RefSeq - XM_006505027 RefSeq - NM_001311060 RefSeq - NM_009311 RefSeq Peptide - NP_001297989 RefSeq Peptide - NP_033337 swissprot - Q149W7 swissprot - B7ZMQ2 swissprot - V9GX83 swissprot - P41539 swissprot - A0A0A0MQA8 Ensembl - ENSMUSG00000061762

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tac1	ENSDARG00000014490	Danio rerio
TAC1	ENSGALG00000009737	Gallus gallus
TAC1	ENSG00000006128	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR008215	Tachykinin domain
IPR008216	Tachykinin family
IPR013055	Tachykinin/Neurokinin-like, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002675	positive regulation of acute inflammatory response	IEA
biological_process	GO:0006954	inflammatory response	IDA
biological_process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA
biological_process	GO:0007217	tachykinin receptor signaling pathway	IBA
biological_process	GO:0007218	neuropeptide signaling pathway	IEA
biological_process	GO:0007267	cell-cell signaling	IBA
biological_process	GO:0007268	chemical synaptic transmission	IEA
biological_process	GO:0007616	long-term memory	IEA
biological_process	GO:0008217	regulation of blood pressure	IEA
biological_process	GO:0008306	associative learning	IEA
biological_process	GO:0009725	response to hormone	IEA
biological_process	GO:0010459	negative regulation of heart rate	IEA
biological_process	GO:0010634	positive regulation of epithelial cell migration	IEA
biological_process	GO:0019233	sensory perception of pain	IMP
biological_process	GO:0032224	positive regulation of synaptic transmission, cholinergic	IEA
biological_process	GO:0032230	positive regulation of synaptic transmission, GABAergic	IEA
biological_process	GO:0032496	response to lipopolysaccharide	IEA
biological_process	GO:0035815	positive regulation of renal sodium excretion	IEA
biological_process	GO:0043278	response to morphine	IEA
biological_process	GO:0045760	positive regulation of action potential	IEA
biological_process	GO:0045778	positive regulation of ossification	IEA
biological_process	GO:0046878	positive regulation of saliva secretion	IEA
biological_process	GO:0048265	response to pain	IMP
biological_process	GO:0050671	positive regulation of lymphocyte proliferation	IEA
biological_process	GO:0051496	positive regulation of stress fiber assembly	IEA
biological_process	GO:1990090	cellular response to nerve growth factor stimulus	IDA
biological_process	GO:2000854	positive regulation of corticosterone secretion	IEA
cellular_component	GO:0005576	extracellular region	IDA
cellular_component	GO:0005615	extracellular space	IBA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0030424	axon	IDA
cellular_component	GO:0043025	neuronal cell body	IDA
molecular_function	GO:0005102	signaling receptor binding	IBA
molecular_function	GO:0031835	substance P receptor binding	IEA

Pathways (from Reactome)

Pathway description

Tachykinin receptors bind tachykinins

G alpha (q) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Ntn1^Gt(ST629)Byg/Ntn1^Gt(ST629)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0001970	abnormal pain threshold	"increased or decreased average level of perception of pain" [J:17792]	Show Allelic Composition: Olfr17^{tm4(Olfr6)Rax}/Olfr17⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003043	hypoalgesia	"decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Ntn1^Gt(ST629)Byg/Ntn1^Gt(ST629)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0003063	increased coping response	"enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ntn1^Gt(ST629)Byg/Ntn1^Gt(ST629)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0003280	urinary incontinence	"inability to control the urinary excretory functions" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Olfr17^{tm4(Olfr6)Rax}/Olfr17⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010386	abnormal urinary bladder physiology	"any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Olfr17^{tm4(Olfr6)Rax}/Olfr17⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020081	Tacr2 / P30549 / tachykinin receptor 2 / P21452*	/ complex / reaction
ENSMUSG00000030043	Tacr1 / P30548 / tachykinin receptor 1 / P25103*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr