ENSG00000115353


Homo sapiens

Features
Gene ID: ENSG00000115353
  
Biological name :TACR1
  
Synonyms : P25103 / tachykinin receptor 1 / TACR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p12
Gene start: 75046463
Gene end: 75199700
  
Corresponding Affymetrix probe sets: 208048_at (Human Genome U133 Plus 2.0 Array)   208049_s_at (Human Genome U133 Plus 2.0 Array)   210637_at (Human Genome U133 Plus 2.0 Array)   230908_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000303522
Ensembl peptide - ENSP00000386448
NCBI entrez gene - 6869     See in Manteia.
OMIM - 162323
RefSeq - NM_001058
RefSeq - NM_015727
RefSeq Peptide - NP_001049
RefSeq Peptide - NP_056542
swissprot - P25103
Ensembl - ENSG00000115353
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tacr1aENSDARG00000035533Danio rerio
 tacr1bENSDARG00000102900Danio rerio
 TACR1ENSGALG00000036638Gallus gallus
 Tacr1ENSMUSG00000030043Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TACR3 / P29371 / tachykinin receptor 3ENSG0000016983658
TACR2 / P21452 / tachykinin receptor 2ENSG0000007507346
GPR83 / Q9NYM4 / G protein-coupled receptor 83ENSG0000012390127
NPY4R / P50391 / neuropeptide Y receptor Y4ENSG0000020417424
NPY4R2 / neuropeptide Y receptor Y4-2ENSG0000026471724
PRLHR / P49683 / prolactin releasing hormone receptorENSG0000011997324
NPY1R / P25929 / neuropeptide Y receptor Y1ENSG0000016412824
NPY2R / P49146 / neuropeptide Y receptor Y2ENSG0000018514922
PROKR2 / Q8NFJ6 / prokineticin receptor 2ENSG0000010129219
PROKR1 / Q8TCW9 / prokineticin receptor 1ENSG0000016961819
NPY5R / Q15761 / neuropeptide Y receptor Y5ENSG0000016412918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000046  Neurokinin NK1 receptor
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001681  Neurokinin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002118 aggressive behavior IEA
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0003051 angiotensin-mediated drinking behavior IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0007217 tachykinin receptor signaling pathway IMP
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009582 detection of abiotic stimulus TAS
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010193 response to ozone IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010996 response to auditory stimulus IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014910 regulation of smooth muscle cell migration IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0032224 positive regulation of synaptic transmission, cholinergic IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035106 operant conditioning IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045760 positive regulation of action potential IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IBA
 biological_processGO:0046878 positive regulation of saliva secretion IEA
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0048266 behavioral response to pain IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0060083 smooth muscle contraction involved in micturition IEA
 biological_processGO:0070472 regulation of uterine smooth muscle contraction IEA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 biological_processGO:1902093 positive regulation of flagellated sperm motility IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0036126 sperm flagellum IDA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0061827 sperm head IDA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0097225 sperm midpiece IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004995 tachykinin receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016496 substance P receptor activity IMP


Pathways (from Reactome)
Pathway description
Tachykinin receptors bind tachykinins
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006128 TAC1 / P20366 / tachykinin precursor 1  / reaction / complex






 

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