ENSG00000075073


Homo sapiens

Features
Gene ID: ENSG00000075073
  
Biological name :TACR2
  
Synonyms : P21452 / tachykinin receptor 2 / TACR2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q22.1
Gene start: 69403903
Gene end: 69416867
  
Corresponding Affymetrix probe sets: 214348_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362403
Ensembl peptide - ENSP00000482436
Ensembl peptide - ENSP00000362404
NCBI entrez gene - 6865     See in Manteia.
OMIM - 162321
RefSeq - NM_001057
RefSeq Peptide - NP_001048
swissprot - A6NEW7
swissprot - A0A087WZ80
swissprot - P21452
Ensembl - ENSG00000075073
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tacr2ENSDARG00000074509Danio rerio
 TACR2ENSGALG00000004248Gallus gallus
 Tacr2ENSMUSG00000020081Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TACR3 / P29371 / tachykinin receptor 3ENSG0000016983651
TACR1 / P25103 / tachykinin receptor 1ENSG0000011535347
GPR83 / Q9NYM4 / G protein-coupled receptor 83ENSG0000012390126
NPY1R / P25929 / neuropeptide Y receptor Y1ENSG0000016412825
PRLHR / P49683 / prolactin releasing hormone receptorENSG0000011997323
NPY2R / P49146 / neuropeptide Y receptor Y2ENSG0000018514923
PROKR2 / Q8NFJ6 / prokineticin receptor 2ENSG0000010129221
PROKR1 / Q8TCW9 / prokineticin receptor 1ENSG0000016961821
NPY4R / P50391 / neuropeptide Y receptor Y4ENSG0000020417421
NPY4R2 / neuropeptide Y receptor Y4-2ENSG0000026471721
NPY5R / Q15761 / neuropeptide Y receptor Y5ENSG0000016412919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000913  Neurokinin NK2 receptor
 IPR001681  Neurokinin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007217 tachykinin receptor signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007588 excretion TAS
 biological_processGO:0014057 positive regulation of acetylcholine secretion, neurotransmission IEA
 biological_processGO:0014827 intestine smooth muscle contraction IEA
 biological_processGO:0033685 negative regulation of luteinizing hormone secretion IEA
 biological_processGO:0035106 operant conditioning IEA
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0043270 positive regulation of ion transport IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IBA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0070459 prolactin secretion IEA
 biological_processGO:0070472 regulation of uterine smooth muscle contraction IEA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 biological_processGO:1902093 positive regulation of flagellated sperm motility IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036126 sperm flagellum IDA
 cellular_componentGO:0061827 sperm head IDA
 cellular_componentGO:0097225 sperm midpiece IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004995 tachykinin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016497 substance K receptor activity IEA


Pathways (from Reactome)
Pathway description
Tachykinin receptors bind tachykinins
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006128 TAC1 / P20366 / tachykinin precursor 1  / complex / reaction






 

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