ENSG00000185149


Homo sapiens

Features
Gene ID: ENSG00000185149
  
Biological name :NPY2R
  
Synonyms : neuropeptide Y receptor Y2 / NPY2R / P49146
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q32.1
Gene start: 155208629
Gene end: 155217078
  
Corresponding Affymetrix probe sets: 208379_x_at (Human Genome U133 Plus 2.0 Array)   210729_at (Human Genome U133 Plus 2.0 Array)   210730_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000332591
Ensembl peptide - ENSP00000426366
NCBI entrez gene - 4887     See in Manteia.
OMIM - 162642
RefSeq - XM_005263034
RefSeq - NM_000910
RefSeq - XM_005263033
RefSeq Peptide - NP_000901
swissprot - P49146
Ensembl - ENSG00000185149
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npy2rENSDARG00000094763Danio rerio
 npy2rlENSDARG00000089943Danio rerio
 NPY2RENSGALG00000009280Gallus gallus
 Npy2rENSMUSG00000028004Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRLHR / P49683 / prolactin releasing hormone receptorENSG0000011997329
NPY4R2 / neuropeptide Y receptor Y4-2ENSG0000026471728
NPY4R / P50391 / neuropeptide Y receptor Y4ENSG0000020417428
GPR83 / Q9NYM4 / G protein-coupled receptor 83ENSG0000012390128
NPY5R / Q15761 / neuropeptide Y receptor Y5ENSG0000016412927
NPY1R / P25929 / neuropeptide Y receptor Y1ENSG0000016412827
PROKR1 / Q8TCW9 / prokineticin receptor 1ENSG0000016961824
PROKR2 / Q8NFJ6 / prokineticin receptor 2ENSG0000010129224
TACR2 / P21452 / tachykinin receptor 2ENSG0000007507324
TACR1 / P25103 / tachykinin receptor 1ENSG0000011535324
TACR3 / P29371 / tachykinin receptor 3ENSG0000016983623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000611  Neuropeptide Y receptor family
 IPR001358  Neuropeptide Y2 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0002793 positive regulation of peptide secretion IEA
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003214 cardiac left ventricle morphogenesis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007626 locomotory behavior TAS
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0031645 negative regulation of neurological system process IEA
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA
 biological_processGO:0046903 secretion IEA
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0051048 negative regulation of secretion IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IEA
 biological_processGO:2000252 negative regulation of feeding behavior IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0001601 peptide YY receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004983 neuropeptide Y receptor activity TAS
 molecular_functionGO:0005246 calcium channel regulator activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108849 PPY / P01298 / pancreatic polypeptide  / reaction / complex
 ENSG00000122585 NPY / P01303 / neuropeptide Y  / reaction / complex
 ENSG00000131096 PYY / P10082 / peptide YY  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr