ENSG00000122585


Homo sapiens

Features
Gene ID: ENSG00000122585
  
Biological name :NPY
  
Synonyms : neuropeptide Y / NPY / P01303
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p15.3
Gene start: 24284163
Gene end: 24291865
  
Corresponding Affymetrix probe sets: 206001_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384364
Ensembl peptide - ENSP00000385282
Ensembl peptide - ENSP00000242152
NCBI entrez gene - 4852     See in Manteia.
OMIM - 162640
RefSeq - NM_000905
RefSeq Peptide - NP_000896
swissprot - A4D158
swissprot - P01303
Ensembl - ENSG00000122585
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npyENSDARG00000036222Danio rerio
 NPYENSGALG00000010983Gallus gallus
 NpyENSMUSG00000029819Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PYY / P10082 / peptide YYENSG0000013109647


Protein motifs (from Interpro)
Interpro ID Name
 IPR001955  Pancreatic hormone-like
 IPR020392  Pancreatic hormone-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006816 calcium ion transport TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007631 feeding behavior TAS
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008343 adult feeding behavior ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021954 central nervous system neuron development IEP
 biological_processGO:0021987 cerebral cortex development IEP
 biological_processGO:0031175 neuron projection development IEP
 biological_processGO:0032098 regulation of appetite IBA
 biological_processGO:0032100 positive regulation of appetite ISS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005623 cell TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity TAS
 molecular_functionGO:0005246 calcium channel regulator activity TAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164129 NPY5R / Q15761 / neuropeptide Y receptor Y5  / complex / reaction
 ENSG00000164128 NPY1R / P25929 / neuropeptide Y receptor Y1  / reaction / complex
 ENSG00000204174 NPY4R / P50391 / neuropeptide Y receptor Y4  / reaction / complex
 ENSG00000185149 NPY2R / P49146 / neuropeptide Y receptor Y2  / reaction / complex






 

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