ENSMUSG00000038071


Mus musculus

Features
Gene ID: ENSMUSG00000038071
  
Biological name :Npy6r
  
Synonyms : Neuropeptide Y receptor type 6 / Npy6r / Q61212
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B3
Gene start: 44270127
Gene end: 44277700
  
Corresponding Affymetrix probe sets: 10455457 (MoGene1.0st)   1422347_at (Mouse Genome 430 2.0 Array)   1438086_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040797
NCBI entrez gene - 18169     See in Manteia.
MGI - MGI:1098590
RefSeq - NM_010935
RefSeq Peptide - NP_035065
swissprot - Q61212
Ensembl - ENSMUSG00000038071
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPY6RENSGALG00000021235Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643751
Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*ENSMUSG0000004833741
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*ENSMUSG0000004401429
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*ENSMUSG0000002800427
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*ENSMUSG0000004505225
Pgr15lENSMUSG0000003121225
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008124
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*ENSMUSG0000004940923
Tacr3 / P47937 / tachykinin receptor 3 / P29371*ENSMUSG0000002817223
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193223
Tacr1 / P30548 / tachykinin receptor 1 / P25103*ENSMUSG0000003004322
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*ENSMUSG0000005055822
Gpr165ENSMUSG0000003121020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000611  Neuropeptide Y receptor family
 IPR000986  Neuropeptide Y6 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0008015 blood circulation IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001601 peptide YY receptor activity IDA
 molecular_functionGO:0001602 pancreatic polypeptide receptor activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004983 neuropeptide Y receptor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc2rtm1Dgen/Mc2rtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004700 abnormal circulating insulin-like growth factor I level "anomalous blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005345 abnormal circulating corticosterone level "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009288 increased epididymal fat pad weight 
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009292 increased inguinal fat pad weight 
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009299 decreased mesenteric fat pad weight 
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009304 increased retroperitoneal fat pad weight 
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012311 decreased defecation amount "decrease in the amount of discharge of feces from the body" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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