ENSMUSG00000048337


Mus musculus

Features
Gene ID: ENSMUSG00000048337
  
Biological name :Npy4r
  
Synonyms : Neuropeptide Y receptor type 4 / Npy4r / Q61041
  
Possible biological names infered from orthology : neuropeptide Y receptor Y4 / neuropeptide Y receptor Y4-2 / NPY4R2 / P50391
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 34143992
Gene end: 34152489
  
Corresponding Affymetrix probe sets: 10418898 (MoGene1.0st)   1422271_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056576
NCBI entrez gene - 19065     See in Manteia.
MGI - MGI:105374
RefSeq - NM_008919
RefSeq Peptide - NP_032945
swissprot - Q61041
Ensembl - ENSMUSG00000048337
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npy4rENSDARG00000043341Danio rerio
 NPY4RENSGALG00000005923Gallus gallus
 NPY4RENSG00000204174Homo sapiens
 NPY4R2ENSG00000264717Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*ENSMUSG0000003643746
Npy6r / Q61212 / Neuropeptide Y receptor type 6 ENSMUSG0000003807141
Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*ENSMUSG0000004401429
Prlhr / Q6VMN6 / Prolactin-releasing peptide receptor / P49683* / prolactin releasing hormone receptor*ENSMUSG0000004505229
Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*ENSMUSG0000002800426
Gpr83 / P30731 / Probable G-protein coupled receptor 83 / Q9NYM4* / G protein-coupled receptor 83*ENSMUSG0000003193225
Tacr3 / P47937 / tachykinin receptor 3 / P29371*ENSMUSG0000002817224
Tacr1 / P30548 / tachykinin receptor 1 / P25103*ENSMUSG0000003004324
Prokr2 / Q8K458 / Prokineticin receptor 2 / Q8NFJ6*ENSMUSG0000005055823
Pgr15lENSMUSG0000003121223
Prokr1 / Q9JKL1 / Mus musculus prokineticin receptor 1 (Prokr1), transcript variant 2, mRNA. / Q8TCW9* / prokineticin receptor 1*ENSMUSG0000004940922
Tacr2 / P30549 / tachykinin receptor 2 / P21452*ENSMUSG0000002008122
Gpr165ENSMUSG0000003121021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000611  Neuropeptide Y receptor family
 IPR001933  Neuropeptide Y4 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0008015 blood circulation IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001601 peptide YY receptor activity IDA
 molecular_functionGO:0001602 pancreatic polypeptide receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004983 neuropeptide Y receptor activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001142 abnormal vaginal opening "a malformed or absent opening to the genital canal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Il4ratm2Tch/Il4ratm2Tch,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?
Genetic Background: B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli

Allelic Composition: Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0004702 increased circulating insulin-like growth factor I level "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004909 increased seminal gland weight "increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0005137 increased growth hormone level "greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Per1tm1Brd/Per1tm1Brd
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0005180 abnormal circulating testosterone level "aberration in the blood concentration of this most potent androgen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0008459 abnormal circulating pancreatic peptide level "anomaly in the amount of the 36-amino acid pancreatic hormone in the blood that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D06.472.699.587.700]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0011385 abnormal testosterone level "anomaly in the concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8]
Show

Allelic Composition: Npy2rtm1.1Hhz/Npy2rtm1.1Hhz,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017311 Pyy / Q9EPS2 / peptide YY / P10082*  / complex / reaction
 ENSMUSG00000017316 Ppy / P10601 / pancreatic polypeptide / P01298*  / complex / reaction
 ENSMUSG00000029819 Npy / P57774 / Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY / P01303* / neuropeptide Y*  / reaction / complex






 

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