ENSMUSG00000093639


Mus musculus

Features
Gene ID: ENSMUSG00000093639
  
Biological name :Lim2
  
Synonyms : Lens fiber membrane intrinsic protein / Lim2 / P56563
  
Possible biological names infered from orthology : lens intrinsic membrane protein 2 / P55344
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 43427670
Gene end: 43435996
  
Corresponding Affymetrix probe sets: 10552398 (MoGene1.0st)   1438323_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004732
NCBI entrez gene - 233187     See in Manteia.
MGI - MGI:104698
RefSeq - NM_177693
RefSeq Peptide - NP_808361
swissprot - P56563
Ensembl - ENSMUSG00000093639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lim2.4ENSDARG00000015445Danio rerio
 lim2.5ENSDARG00000041295Danio rerio
 LIM2ENSG00000105370Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003935  Lens fibre membrane intrinsic protein
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR004032  PMP-22/EMP/MP20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0043010 camera-type eye development IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005212 structural constituent of eye lens TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

Allelic Composition: Lim2Aca47/Lim2+
Genetic Background: C57BL/6J-Lim2Aca47

Allelic Composition: Lim2Aca47/Lim2Aca47
Genetic Background: C57BL/6J-Lim2Aca47

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Lim2Aca47/Lim2Aca47
Genetic Background: C57BL/6J-Lim2Aca47

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

Allelic Composition: Lim2Aca47/Lim2+
Genetic Background: C57BL/6J-Lim2Aca47

Allelic Composition: Lim2Aca47/Lim2Aca47
Genetic Background: C57BL/6J-Lim2Aca47

 MP:0002579 disorganized secondary lens fibers "deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lim2Aca47/Lim2+
Genetic Background: C57BL/6J-Lim2Aca47

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Lim2Aca47/Lim2Aca47
Genetic Background: C57BL/6J-Lim2Aca47

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Lim2Aca47/Lim2Aca47
Genetic Background: C57BL/6J-Lim2Aca47

 MP:0010263 total cataracts "a lens opacity which involves both nuclear and cortical regions, including all fibers of a lens; usually congenital" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Lim2To3/Lim2+
Genetic Background: involves: 102 * C3H/He * T STOCK

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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