Manteia - Molecule gene

ENSMUSG00000095105

Mus musculus

Features

Gene ID:	ENSMUSG00000095105

Biological name :	Edaradd

Synonyms :	Edaradd / EDAR associated death domain

Possible biological names infered from orthology :	Q8WWZ3

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	A1
Gene start:	12472632
Gene end:	12520438

Corresponding Affymetrix probe sets:	10407782 (MoGene1.0st) 1421213_at (Mouse Genome 430 2.0 Array) 1433132_at (Mouse Genome 430 2.0 Array) 1433133_at (Mouse Genome 430 2.0 Array) 1437800_at (Mouse Genome 430 2.0 Array) 1440162_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000136158 NCBI entrez gene - 171211 See in Manteia. MGI - MGI:1931001 RefSeq - NM_133643 RefSeq - XM_006516564 RefSeq Peptide - NP_598398 swissprot - Q5D0F1 Ensembl - ENSMUSG00000095105

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
edaradd	ENSDARG00000062289	Danio rerio
EDARADD	ENSGALG00000031763	Gallus gallus
Q8WWZ3	ENSG00000186197	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000488	Death domain
IPR011029	Death-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

TNFs bind their physiological receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000017	big ears	"outer ears of a greater than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Edaradd^cr-2Btlr/Edaradd^cr-2Btlr Genetic Background: C57BL/6J-Edaradd^cr-2Btlr
MP:0000367	abnormal coat/ hair morphology	"anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0000382	underdeveloped hair follicles	"arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Ift172^wim/Del(5D5Mit73-D5Mit351)5Jcs Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0000417	short hair	"reduced average length of the hairs" [J:64948]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0000418	patchy hair	"uneven spots of hair growth on the body" [J:26975]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred Allelic Composition: Edaradd^cr-Btlr/Edaradd^cr-Btlr Genetic Background: C57BL/6J-Edaradd^cr-Btlr Allelic Composition: Edaradd^cr-2Btlr/Edaradd^cr-2Btlr Genetic Background: C57BL/6J-Edaradd^cr-2Btlr
MP:0000422	delayed hair appearance	"late onset of the first appearance of the fur" [J:17792]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H Allelic Composition: Edaradd^cr-2J/Edaradd^cr-2J Genetic Background: involves: C3HeB/FeJLe * C57BL/6J Allelic Composition: Edaradd^cr-Btlr/Edaradd^cr-Btlr Genetic Background: C57BL/6J-Edaradd^cr-Btlr
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: B6C3Fe a/a-Edaradd^cr/J
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: B6C3Fe a/a-Edaradd^cr/J
MP:0000876	Purkinje cell degeneration	"a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: B6C3Fe a/a-Edaradd^cr/J
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: B6C3Fe a/a-Edaradd^cr/J
MP:0001199	thin skin	"reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0001244	thin dermal layer	"reduced thickness of the dermis" [J:65030]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Edaradd^cr-Btlr/Edaradd^cr-Btlr Genetic Background: C57BL/6J-Edaradd^cr-Btlr
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0001510	abnormal coat appearance	"coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Edaradd^cr-2Btlr/Edaradd^cr-2Btlr Genetic Background: C57BL/6J-Edaradd^cr-2Btlr
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Eda^Ta-6J/Eda⁺ Genetic Background: C57BL/6J A^w-J-Eda^Ta-6J/J
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Ift172^wim/Del(5D5Mit73-D5Mit351)5Jcs Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: B6C3Fe a/a-Edaradd^cr/J
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0001943	abnormal respiration	"anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred Allelic Composition: Edaradd^cr-2Btlr/Edaradd^cr-2Btlr Genetic Background: C57BL/6J-Edaradd^cr-2Btlr
MP:0001950	abnormal respiratory sounds	"anomalous noises heard over any part of the respiratory tract" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ift172^wim/Del(5D5Mit73-D5Mit351)5Jcs Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6J
MP:0002074	abnormal hair texture	"irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0002095	abnormal skin pigmentation	"variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0002100	abnormal tooth morphology	"atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred Allelic Composition: Edaradd^cr-Btlr/Edaradd^cr-Btlr Genetic Background: C57BL/6J-Edaradd^cr-Btlr
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ift172^wim/Del(5D5Mit73-D5Mit351)5Jcs Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Eda^Ta-6J/Eda⁺ Genetic Background: C57BL/6J A^w-J-Eda^Ta-6J/J
MP:0002177	abnormal outer ear morphology	"malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Ssm/Kit⁺ Genetic Background: involves: C57BL/10 * Non-inbred
MP:0002277	abnormal respiratory mucosa morphology	"structural anomaly of the mucous membrane lining the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Eda^Ta-6J/Eda⁺ Genetic Background: C57BL/6J A^w-J-Eda^Ta-6J/J
MP:0002576	abnormal enamel morphology	"malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0003312	abnormal locomotor coordination	"reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: B6C3Fe a/a-Edaradd^cr/J
MP:0003704	abnormal hair follicle development	"anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0003932	abnormal molar crown morphology	"defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Antxr1^tm1.2Lepp/Antxr1^tm1.2Lepp,Antxr2^tm1.2Lepp/Antxr2^tm1.2Lepp Genetic Background: involves: 129 * C57BL/6
MP:0005287	narrow eye opening	"less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0005358	abnormal incisor morphology	"structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0006236	absent meibomian glands	"missing meibomian glands" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0006365	absent guard hair	"absence of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0006366	absent zigzag hairs	"absence of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0006400	decreased molar number	"reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0006402	small molars	"reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H Allelic Composition: Eda^Ta/Eda⁺,Edaradd^cr/Edaradd⁺ Genetic Background: involves: JU/Fa
MP:0009267	abnormal cerebellum fissure morphology	"any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: B6C3Fe a/a-Edaradd^cr/J
MP:0009825	cornea ulcer	"an area of tissue erosion in the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0009956	abnormal cerebellar layer morphology	"any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: B6C3Fe a/a-Edaradd^cr/J
MP:0012078	abnormal tail ring morphology	"any structural anomaly of the segmentally patterned skin ridges appearing on the tail of rodents" [MGI:csmith]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0013176	abnormal tail position or orientation	" tail is displaced from the normal location and/or does not orient in a typical pattern" [MGI:anna]	Show Allelic Composition: Edaradd^cr-Btlr/Edaradd^cr-Btlr Genetic Background: C57BL/6J-Edaradd^cr-Btlr
MP:0013897	decreased eyelid cilium number	"reduction in the number of the hairs that grow at the edge of the upper or lower eyelid" [MGI:Anna]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H
MP:0030457	abnormal molar cusp morphology	"any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]	Show Allelic Composition: Edaradd^cr/Edaradd^cr Genetic Background: involves: C57BL/6 * C3H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000003227	Edar / Q9R187 / Tumor necrosis factor receptor superfamily member EDAR / Q9UNE0* / ectodysplasin A receptor*	/ reaction / complex
ENSMUSG00000059327	Eda / O54693 / Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form / Q92838* / ectodysplasin A*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr