ENSMUSG00000003227


Mus musculus

Features
Gene ID: ENSMUSG00000003227
  
Biological name :Edar
  
Synonyms : Edar / Q9R187 / Tumor necrosis factor receptor superfamily member EDAR
  
Possible biological names infered from orthology : ectodysplasin A receptor / Q9UNE0
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 58600789
Gene end: 58675654
  
Corresponding Affymetrix probe sets: 10369236 (MoGene1.0st)   1419724_at (Mouse Genome 430 2.0 Array)   1447498_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003312
NCBI entrez gene - 13608     See in Manteia.
MGI - MGI:1343498
RefSeq - XM_006513206
RefSeq - NM_010100
RefSeq - XM_006513204
RefSeq - XM_006513205
RefSeq Peptide - NP_034230
swissprot - Q9R187
Ensembl - ENSMUSG00000003227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edarENSDARG00000099088Danio rerio
 EDARENSGALG00000016809Gallus gallus
 EDARENSG00000135960Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011029  Death-like domain superfamily
 IPR034052  Tumor necrosis factor receptor EDAR, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0046330 positive regulation of JNK cascade IBA
 biological_processGO:0060662 salivary gland cavitation IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Cnga2tm1Reed/Y
Genetic Background: involves: 129/Sv * BALB/cJ

 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Edartm1.1Bamo/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0000405 abnormal auchene hairs "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbxl21Psttm/Fbxl21Psttm
Genetic Background: involves: BTBR * C57BL/6J

 MP:0000408 absent duvet hair "missing duvet hair " [J:46854]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0000411 shiny fur "fur with a glossy or glistening appearance" [J:45065]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: EdarTg(OVE1B)Ove/EdarTg(OVE1B)Ove
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: EdarTg(OVE1B)Ove/EdarTg(OVE1B)Ove
Genetic Background: involves: C3H * C57BL/6 * FVB/N

Allelic Composition: Edardl-Btlr/Edardl-Btlr
Genetic Background: C57BL/6J-Edardl-Btlr

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: EdarTg(OVE1B)Ove/EdarTg(OVE1B)Ove
Genetic Background: involves: C3H * C57BL/6 * FVB/N

Allelic Composition: Edardl-Btlr/Edardl-Btlr
Genetic Background: C57BL/6J-Edardl-Btlr

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Edartm1.1Bamo/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: EdarTg(OVE1B)Ove/EdarTg(OVE1B)Ove
Genetic Background: involves: C3H * C57BL/6 * FVB/N

Allelic Composition: EdarTg(OVE1A)Ove/EdarTg(OVE1A)Ove
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Edardl-Btlr/Edardl-Btlr
Genetic Background: C57BL/6J-Edardl-Btlr

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0003791 abnormal minor salivary gland morphology "any structural malformations of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

 MP:0003849 greasy coat "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: EdarTg(OVE1B)Ove/EdarTg(OVE1B)Ove
Genetic Background: involves: C3H * C57BL/6 * FVB/N

Allelic Composition: EdarDl-slk2H/Edar+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: EdarDl-slk2H/EdarDl-slk2H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003931 absent molars "missing the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: EdarDl-slk2H/Edar+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: EdarDl-slk2H/EdarDl-slk2H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0006236 absent meibomian glands "missing meibomian glands" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: EdarTg(OVE1B)Ove/EdarTg(OVE1B)Ove
Genetic Background: involves: C3H * C57BL/6 * FVB/N

Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

 MP:0006258 abnormal circumvallate papillae "malformation, absence, or atypical size or shape of the large papillae, which have multiple taste buds in the trough surrounding the papillae, located near the base and on the dorsal side of the tongue" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

 MP:0006363 absent auchene hairs "absence of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0006365 absent guard hair "absence of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: EdarTg(OVE1B)Ove/EdarTg(OVE1B)Ove
Genetic Background: involves: C3H * C57BL/6 * FVB/N

Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: C3HeB/FeJ

 MP:0006366 absent zigzag hairs "absence of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0006367 absent sweat gland "absence of any of the coil glands of the skin that secrete sweat" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

 MP:0006400 decreased molar number "reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0006402 small molars "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0008904 abnormal mammary fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Edartm1.1Bamo/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0009003 abnormal vibrissa number "any anomaly in the number of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors" [MESH:A13.950, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0009533 absent palatine gland "absence of the salivary gland of the hard palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

 MP:0009534 absent anterior lingual gland "absence of the small glands located near the apex of the tongue on either side of the frenulum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

 MP:0010233 hairless tail "the tail is devoid of hair" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: EdarDl-slk2H/EdarDl-slk2H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0010864 abnormal enamel knot morphology "any structural anomaly of a transient cluster of cells in the central part of the dental epithelium facing the dental mesenchyme, which acts as an organizing center, providing positional information for tooth morphogenesis and regulating the growth of tooth cusps" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8808404]
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Allelic Composition: Edardl-J/Edardl-J
Genetic Background: involves: FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0013176 abnormal tail position or orientation " tail is displaced from the normal location and/or does not orient in a typical pattern" [MGI:anna]
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Allelic Composition: Edardl-Btlr/Edardl-Btlr
Genetic Background: C57BL/6J-Edardl-Btlr

 MP:0013457 increased eccrine gland number "greater than normal numbers of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present " [MGI:Anna]
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Allelic Composition: Edartm1.1Bamo/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Edartm1.1Bamo/Edar+
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

 MP:0013458 decreased eccrine gland number "fewer than normal numbers of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present " [MGI:Anna]
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Allelic Composition: Edartm1.1Bamo/Edar+
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0030079 small incisors "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
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Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

 MP:0030494 abnormal molar root morphology "any structural anomaly of the part of a molar tooth that is implanted in the gum" [MGI:anna]
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Allelic Composition: EdarDl-slk/Edar+
Genetic Background: Not Specified

Allelic Composition: EdarDl-slk/EdarDl-slk
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059327 Eda / O54693 / Ectodysplasin-A Ectodysplasin-A, membrane form Ectodysplasin-A, secreted form / Q92838* / ectodysplasin A*  / complex / reaction
 ENSMUSG00000095105 Edaradd / EDAR associated death domain / Q8WWZ3*  / reaction / complex






 

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