ENSDARG00000001929


Danio rerio

Features
Gene ID: ENSDARG00000001929
  
Biological name :pink1
  
Synonyms : pink1 / PTEN induced putative kinase 1
  
Possible biological names infered from orthology : Q99MQ3 / Q9BXM7 / Serine/threonine-protein kinase PINK1, mitochondrial
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 37466967
Gene end: 37480785
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000014981
swissprot - F1QTR3
ZFIN ID - ZDB-GENE-041212-53
Ensembl - ENSDARG00000001929
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PINK1ENSGALG00000037593Gallus gallus
 PINK1ENSG00000158828Homo sapiens
 Pink1ENSMUSG00000028756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000422 autophagy of mitochondrion IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0048823 nucleate erythrocyte development IMP
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0060872 semicircular canal development IMP
 biological_processGO:0071542 dopaminergic neuron differentiation IMP
 biological_processGO:0090141 positive regulation of mitochondrial fission IBA
 biological_processGO:1900746 regulation of vascular endothelial growth factor signaling pathway IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain proliferative region increased size , abnormal
brain apoptotic , abnormal
brain increased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000075 spinal cord spinal cord apoptotic , abnormal
spinal cord curved ventral , abnormal
spinal cord Rohon-Beard neuron decreased amount , abnormal
spinal cord primary motor neuron decreased amount , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dopaminergic neuron decreased amount , abnormal
diencephalon dopaminergic neuron spatial pattern , abnormal
diencephalon dopaminergic neuron distributed , abnormal
diencephalon dopaminergic neuron mislocalised ventrally , abnormal
diencephalon has number of diencephalon dopaminergic neuron, ameliorated
diencephalon has fewer parts of type diencephalon dopaminergic neuron, abnormal
Show

 ZFA:0000106 extension extension decreased width , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000128 midbrain midbrain dopaminergic neuron decreased amount , abnormal
midbrain dopaminergic neuron decreased amount , exacerbated
Show

 ZFA:0000155 somite somite shape , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
Show

 ZFA:0000318 brainstem and spinal white matter brainstem and spinal white matter disorganized , abnormal
Show

 ZFA:0000418 pretectum pretectum dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0000445 optic tectum optic tectum morphology , abnormal
Show

 ZFA:0000618 ansulate commissure ansulate commissure aplastic , abnormal
Show

 ZFA:0000633 caudal tuberculum caudal tuberculum dopaminergic neuron dead , abnormal
caudal tuberculum dopaminergic neuron disheveled , abnormal
Show

 ZFA:0001058 caudal fin caudal fin shape , abnormal
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 ZFA:0001094 whole organism whole organism decreased speed , abnormal
whole organism movement behavioral quality , abnormal
whole organism NADH dehydrogenase (ubiquinone) activity decreased occurrence , abnormal
whole organism increased amount , abnormal
whole organism ATP decreased amount , abnormal
whole organism ATP decreased amount , ameliorated
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 ZFA:0001114 head head morphology , abnormal
head low brightness , abnormal
head opaque , abnormal
head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region curved ventral , abnormal
Show

 ZFA:0001682 white matter white matter shape , abnormal
Show

 ZFA:0005145 muscle muscle mitochondrion increased size , abnormal
muscle mitochondrion decreased functionality , abnormal
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 ZFA:0009063 peripheral neuron peripheral neuron decreased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased amount , abnormal
nucleate erythrocyte normal amount , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron decreased amount , abnormal
dopaminergic neuron axon absent , abnormal
dopaminergic neuron axon decreased length , abnormal
dopaminergic neuron axon broken , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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