ENSGALG00000037593


Gallus gallus

Features
Gene ID: ENSGALG00000037593
  
Biological name :PINK1
  
Synonyms : PINK1 / PTEN induced putative kinase 1
  
Possible biological names infered from orthology : Q99MQ3 / Q9BXM7 / Serine/threonine-protein kinase PINK1, mitochondrial
  
Species: Gallus gallus
  
Chr. number: 21
Strand: 1
Band:
Gene start: 4897154
Gene end: 4903786
  
Corresponding Affymetrix probe sets: Gga.7135.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047654
NCBI entrez gene - 425370     See in Manteia.
RefSeq - XM_423139
swissprot - A0A1D5P4P2
Ensembl - ENSGALG00000037593
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pink1ENSDARG00000001929Danio rerio
 PINK1ENSG00000158828Homo sapiens
 Pink1ENSMUSG00000028756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000422 autophagy of mitochondrion IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002082 regulation of oxidative phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0010310 regulation of hydrogen peroxide metabolic process IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010821 regulation of mitochondrion organization IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0016242 negative regulation of macroautophagy IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0022904 respiratory electron transport chain IEA
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0033605 positive regulation of catecholamine secretion IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072655 establishment of protein localization to mitochondrion IEA
 biological_processGO:0072656 maintenance of protein location in mitochondrion IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0090258 negative regulation of mitochondrial fission IEA
 biological_processGO:0097237 cellular response to toxic substance IEA
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0099074 mitochondrion to lysosome transport IEA
 biological_processGO:1900407 regulation of cellular response to oxidative stress IEA
 biological_processGO:1901727 positive regulation of histone deacetylase activity IEA
 biological_processGO:1902902 negative regulation of autophagosome assembly IEA
 biological_processGO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone IEA
 biological_processGO:1903147 negative regulation of autophagy of mitochondrion IEA
 biological_processGO:1903202 negative regulation of oxidative stress-induced cell death IEA
 biological_processGO:1903214 regulation of protein targeting to mitochondrion IEA
 biological_processGO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IEA
 biological_processGO:1903852 positive regulation of cristae formation IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005742 mitochondrial outer membrane translocase complex IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IEA
 cellular_componentGO:0031932 TORC2 complex IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097449 astrocyte projection IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0010857 calcium-dependent protein kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011562 PRKN / parkin RBR E3 ubiquitin protein ligase / Park2* / O60260* / Q9WVS6* / E3 ubiquitin-protein ligase parkin *  / complex / reaction






 

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