ENSDARG00000002663


Danio rerio

Features
Gene ID: ENSDARG00000002663
  
Biological name :optn
  
Synonyms : optineurin / optn
  
Possible biological names infered from orthology : Mus musculus optineurin (Optn), transcript variant 1, mRNA. / Q8K3K8 / Q96CV9
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 8016457
Gene end: 8027318
  
Corresponding Affymetrix probe sets: Dr.20525.1.A1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000020714
Ensembl peptide - ENSDARP00000116787
NCBI entrez gene - 336159     See in Manteia.
RefSeq - NM_001100066
RefSeq - XM_021474936
RefSeq Peptide - NP_001093536
swissprot - A5WUQ0
swissprot - A5WUP9
ZFIN ID - ZDB-GENE-030131-8103
Ensembl - ENSDARG00000002663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OPTNENSGALG00000013738Gallus gallus
 OPTNENSG00000123240Homo sapiens
 OptnENSMUSG00000026672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*ENSDARG0000001703727


Protein motifs (from Interpro)
Interpro ID Name
 IPR021063  NF-kappa-B essential modulator NEMO, N-terminal
 IPR032419  NF-kappa-B essential modulator NEMO, CC2-LZ domain
 IPR032939  Optineurin
 IPR034735  NEMO, Zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0000107 eye eye decreased area , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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 ZFA:0001114 head head cell apoptotic , abnormal
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 ZFA:0001115 trunk trunk cell apoptotic , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
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 ZFA:0009052 motor neuron motor neuron axon decreased length , abnormal
motor neuron axon increased branchiness , abnormal
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 ZFA:0009090 pigment cell pigment cell decreased perimeter , abnormal
pigment cell cell projection increased amount , abnormal
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 ZFA:0009248 neuron neuron vesicle decreased speed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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