ENSDARG00000017037


Danio rerio

Features
Gene ID: ENSDARG00000017037
  
Biological name :ikbkg
  
Synonyms : ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  
Possible biological names infered from orthology : inhibitor of nuclear factor kappa B kinase subunit gamma / NF-kappa-B essential modulator / O88522 / Q9Y6K9
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 18574221
Gene end: 18597709
  
Corresponding Affymetrix probe sets: Dr.6051.1.A1_at (Zebrafish Array)   NM_001014344_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000154035
Ensembl peptide - ENSDARP00000107606
Ensembl peptide - ENSDARP00000154488
Ensembl peptide - ENSDARP00000027612
NCBI entrez gene - 541530     See in Manteia.
RefSeq - NM_001014344
RefSeq Peptide - NP_001014366
swissprot - F1QHG7
swissprot - F1QHM5
ZFIN ID - ZDB-GENE-050327-68
Ensembl - ENSDARG00000017037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IKBKGENSG00000269335Homo sapiens
 IkbkgENSMUSG00000004221Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
optn / optineurin / Q8K3K8* / Q96CV9* / Mus musculus optineurin (Optn), transcript variant 1, mRNA.*ENSDARG0000000266324


Protein motifs (from Interpro)
Interpro ID Name
 IPR021063  NF-kappa-B essential modulator NEMO, N-terminal
 IPR032419  NF-kappa-B essential modulator NEMO, CC2-LZ domain
 IPR034735  NEMO, Zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007252 I-kappaB phosphorylation IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0008385 IkappaB kinase complex IBA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism curved , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000021509 tab2 / Q5RFW2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q9NYJ8* / Q99K90* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / reaction
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / reaction
 ENSDARG00000030087 nfkbib / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta / Q15653* / Q60778* / NFKB inhibitor beta* / NF-kappa-B inhibitor beta *  / reaction
 ENSDARG00000031954 rbck1 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / Q9WUB0* / RANBP2-type and C3HC4-type zinc finger containing 1*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000062063 tab3 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSDARG00000059871 A9JTG5 / shrprbck1r / sharpin and rbck1 related / Q9H0F6* / Q91WA6* / SHARPIN* / SHANK associated RH domain interactor*  / complex / reaction
 ENSDARG00000055276 rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*  / reaction
 ENSDARG00000041619 rack1 / O42248 / receptor for activated C kinase 1 / P68040* / P63244* / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed*  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / complex / reaction
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / complex / reaction
 ENSDARG00000010756 nod2 / nucleotide-binding oligomerization domain containing 2 / Q8K3Z0* / Q9HC29* / Nucleotide-binding oligomerization domain-containing protein 2 *  / complex / reaction
 ENSDARG00000076995 sharpin / SHANK-associated RH domain interacting protein / Q91WA6* / Q9H0F6* / SHANK associated RH domain interactor*  / complex / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000027777 tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / Q60769* / TNF alpha induced protein 3*  / reaction
 ENSDARG00000060058 cylda / cylindromatosis (turban tumor syndrome), a / CYLD* / Q80TQ2* / Q9NQC7* / CYLD lysine 63 deubiquitinase* / Ubiquitin carboxyl-terminal hydrolase CYLD *  / complex / reaction






 

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