ENSDARG00000007438


Danio rerio

Features
Gene ID: ENSDARG00000007438
  
Biological name :ube2ib
  
Synonyms : Q9W6H5 / ube2ib / ubiquitin-conjugating enzyme E2Ib
  
Possible biological names infered from orthology : P63279 / P63280 / UBE2I / ubiquitin conjugating enzyme E2 I
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 37257596
Gene end: 37272116
  
Corresponding Affymetrix probe sets: Dr.8127.1.S1_at (Zebrafish Array)   NM_131351_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000011487
NCBI entrez gene - 30622     See in Manteia.
RefSeq - NM_131351
RefSeq Peptide - NP_571426
swissprot - Q9W6H5
ZFIN ID - ZDB-GENE-990614-17
Ensembl - ENSDARG00000007438
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UBE2IENSGALG00000006428Gallus gallus
 UBE2IENSG00000103275Homo sapiens
 Ube2iENSMUSG00000015120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*ENSDARG0000005264999


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site
 IPR027230  SUMO-conjugating enzyme Ubc9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IGI
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007088 regulation of mitotic nuclear division IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016925 protein sumoylation IMP
 biological_processGO:0031099 regeneration IMP
 biological_processGO:0036306 embryonic heart tube elongation IGI
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060216 definitive hemopoiesis IGI
 biological_processGO:0061484 hematopoietic stem cell homeostasis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity IMP


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000094 blood island blood island hematopoietic stem cell decreased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye apoptotic , abnormal
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 ZFA:0000152 retina retina has fewer parts of type Muller cell , abnormal
retina regeneration process quality , abnormal
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 ZFA:0000360 heart tube heart tube shortened , abnormal
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 ZFA:0000488 ceratobranchial bone ceratobranchial bone malformed , abnormal
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 ZFA:0001078 thymus thymus lymphoid progenitor cell absent , abnormal
thymus lymphoid progenitor cell aplastic , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton malformed , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage chondrocyte decreased amount , abnormal
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 ZFA:0005041 anterior lateral plate mesoderm anterior lateral plate mesoderm increased distribution , abnormal
anterior lateral plate mesoderm decreased amount , abnormal
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 ZFA:0009084 chondrocyte chondrocyte increased size , abnormal
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 ZFA:0009324 myeloid cell myeloid cell decreased amount , abnormal
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 ZFA:0009325 erythroid lineage cell erythroid lineage cell decreased amount , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
hematopoietic multipotent progenitor cell cell proliferation decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000000151 thraa / Q98867 / thyroid hormone receptor alpha a / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*  / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSDARG00000010487 sae1 / Q6IQS6 / SUMO1 activating enzyme subunit 1 / Q9UBE0* / Q9R1T2* / SUMO-activating enzyme subunit 1 SUMO-activating enzyme subunit 1, N-terminally processed*  / reaction
 ENSDARG00000026225 nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / reaction
 ENSDARG00000021163 thrb / Q9PVE4 / thyroid hormone receptor beta / P10828* / P37242*  / reaction
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / reaction
 ENSDARG00000030756 dnmt1 / DNA (cytosine-5-)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / reaction
 ENSDARG00000005274 rad52 / RAD52 homolog, DNA repair protein / P43351* / P43352*  / reaction
 ENSDARG00000010732 xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000014329 npm1a / nucleophosmin 1a / NPM1* / Q61937* / P06748* / nucleophosmin 1*  / reaction
 ENSDARG00000019103 kdm4ab / lysine (K)-specific demethylase 4A, genome duplicate b / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *  / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / complex / reaction
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / complex / reaction
 ENSDARG00000034893 rarab / Q7ZTI3 / retinoic acid receptor, alpha b / RARA* / P11416* / P10276* / retinoic acid receptor alpha*  / reaction
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000019213 zgc:136929 / CTBP1* / O88712* / Q13363* / C-terminal binding protein 1*  / reaction
 ENSDARG00000057737 rxraa / retinoid X receptor, alpha a / RXRA* / P19793* / P28700* / retinoid X receptor alpha*  / reaction
 ENSDARG00000025032 nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*  / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / reaction
 ENSDARG00000056783 raraa / Q90271 / retinoic acid receptor, alpha a / RARA* / P11416* / P10276* / retinoic acid receptor alpha*  / reaction
 ENSDARG00000059812 sin3ab / SIN3 transcription regulator family member Ab / SIN3A* / Q96ST3* / Q60520* / SIN3 transcription regulator family member A* / Mus musculus transcriptional regulator, SIN3A (yeast) (...  / reaction
 ENSDARG00000055359 sp100.1 / SP110 nuclear body protein, tandem duplicate 1 / SP110* / SP140* / SP100* / SP140L* / Q9H930* / O35892* / P23497* / Q13342* / Q8BVK9* / Q9HB58* / A630001G21Rik* / A530032D15Rik* /...  / reaction
 ENSDARG00000044949 rnf8 / ring finger protein 8, E3 ubiquitin protein ligase / Q8VC56* / O76064* / Gm28043* / ring finger protein 8* / E3 ubiquitin-protein ligase RNF8 *  / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000079716 sin3aa / SIN3 transcription regulator family member Aa / SIN3A* / Q96ST3* / Q60520* / SIN3 transcription regulator family member A* / Mus musculus transcriptional regulator, SIN3A (yeast) (...  / reaction
 ENSDARG00000073841 herc2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / reaction
 ENSDARG00000090449 sp100.3 / SP110 nuclear body protein, tandem duplicate 3 / SP110* / SP140* / SP100* / SP140L* / Q9H930* / O35892* / P23497* / Q13342* / Q8BVK9* / Q9HB58* / A630001G21Rik* / A530032D15Rik* /...  / reaction
 ENSDARG00000086764 mdc1 / mediator of DNA damage checkpoint 1 / Q14676*  / reaction
 ENSDARG00000010873 si:dkey-156n14.5 / DDX17* / Q92841* / DEAD-box helicase 17*  / reaction
 ENSDARG00000031777 pparaa / peroxisome proliferator-activated receptor alpha a / PPARA* / P23204* / Q07869* / peroxisome proliferator activated receptor alpha*  / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction
 ENSDARG00000042215 pias4b / protein inhibitor of activated STAT, 4b / PIAS4* / Q9JM05* / Q8N2W9* / protein inhibitor of activated STAT 4*  / reaction
 ENSDARG00000054323 pparab / peroxisome proliferator-activated receptor alpha b / PPARA* / P23204* / Q07869* / peroxisome proliferator activated receptor alpha*  / reaction
 ENSDARG00000018782 kdm4aa / lysine (K)-specific demethylase 4A, genome duplicate a / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *  / reaction
 ENSDARG00000104907 ing2 / inhibitor of growth family, member 2 / Q9ESK4* / Q9H160* / Inhibitor of growth protein 2 *  / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction
 ENSDARG00000099675 kdm4b / lysine (K)-specific demethylase 4B / O94953* / Q91VY5* / lysine demethylase 4B* / Lysine-specific demethylase 4B *  / reaction
 ENSDARG00000101510 cetn2 / centrin, EF-hand protein, 2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / reaction
 ENSDARG00000100940 nr5a2 / nuclear receptor subfamily 5, group A, member 2 / O00482*  / reaction
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / reaction
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / reaction
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / reaction
 ENSDARG00000007198 mta1 / metastasis associated 1 / Q13330* / Q8K4B0* / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA.*  / reaction
 ENSDARG00000028198 Q6PEH5 / ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction
 ENSDARG00000018257 ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / reaction
 ENSDARG00000029766 nr1i2 / nuclear receptor subfamily 1, group I, member 2 / O54915* / O75469*  / reaction
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / reaction
 ENSDARG00000038687 nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*  / reaction
 ENSDARG00000055493 hic1 / hypermethylated in cancer 1 / Q14526* / HIC ZBTB transcriptional repressor 1*  / reaction
 ENSDARG00000039754 xpc / xeroderma pigmentosum, complementation group C / P51612* / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / reaction
 ENSDARG00000056079 l3mbtl2 / l(3)mbt-like 2 (Drosophila) / P59178* / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit* / Lethal(3)malignant brain tumor-like protein 2 *  / reaction
 ENSDARG00000042180 foxl2a / forkhead box L2a / FOXL2* / O88470* / P58012* / forkhead box L2* / Forkhead box protein L2 *  / reaction
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction
 ENSDARG00000061885 satb2 / SATB homeobox 2 / Q8VI24* / Q9UPW6* / special AT-rich sequence binding protein 2*  / reaction
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction
 ENSDARG00000036791 dnmt3bb.1 / DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1 / Q9UBC3* / DNMT3B* / Dnmt3c* / O88509* / DNA methyltransferase 3 beta* / DNA (cytosine-5)-methyltransferase 3B *  / reaction
 ENSDARG00000000729 daxx / death-domain associated protein / Q9UER7* / Mus musculus Fas death domain-associated protein (Daxx), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000070721 vdrb / Q1L673 / vitamin D receptor b / VDR* / P48281* / P11473* / vitamin D receptor* / vitamin D (1,25-dihydroxyvitamin D3) receptor*  / reaction
 ENSDARG00000037260 toporsa / topoisomerase I binding, arginine/serine-rich a / TOPORS* / Q80Z37* / Q9NS56* / E3 ubiquitin-protein ligase Topors * / TOP1 binding arginine/serine rich protein*  / reaction
 ENSDARG00000068965 nrip1a / nuclear receptor interacting protein 1a / NRIP1* / Q8CBD1* / P48552* / nuclear receptor interacting protein 1* / Mus musculus nuclear receptor interacting protein 1 (Nrip1), transc...  / reaction
 ENSDARG00000068417 foxl2b / forkhead box L2b / FOXL2* / P58012* / forkhead box L2*  / reaction
 ENSDARG00000067976 ar / androgen receptor / P10275* / P19091*  / reaction
 ENSDARG00000024488 top2a / DNA topoisomerase II alpha / P11388* / Q01320* / DNA topoisomerase 2-alpha *  / reaction
 ENSDARG00000034195 top2b / DNA topoisomerase II beta / Q02880* / Q64511* / DNA topoisomerase 2-beta *  / reaction
 ENSDARG00000040606 tfap2c / transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) / Q61312* / Q92754* / transcription factor AP-2 gamma*  / reaction
 ENSDARG00000052654 thrab / thyroid hormone receptor alpha b / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*  / reaction
 ENSDARG00000068894 nrip1b / nuclear receptor interacting protein 1b / NRIP1* / Q8CBD1* / P48552* / nuclear receptor interacting protein 1* / Mus musculus nuclear receptor interacting protein 1 (Nrip1), transc...  / reaction
 ENSDARG00000098439 nr1h3 / nuclear receptor subfamily 1, group H, member 3 / Q13133*  / reaction
 ENSDARG00000098924 suz12b / B0R1D5 / SUZ12 polycomb repressive complex 2b subunit / SUZ12* / Q80U70* / Q15022* / Polycomb protein Suz12 * / SUZ12 polycomb repressive complex 2 subunit*  / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / complex / reaction
 ENSDARG00000102082 nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*  / reaction
 ENSDARG00000098211 wrn / Werner syndrome / O09053* / Q14191* / Werner syndrome RecQ like helicase*  / reaction
 ENSDARG00000101332 uba2 / Q7SXG4 / ubiquitin-like modifier activating enzyme 2 / Q9UBT2* / Q9Z1F9*  / reaction
 ENSDARG00000104353 nop58 / NOP58 ribonucleoprotein homolog (yeast) / Q6DFW4* / Q9Y2X3* / Nucleolar protein 58 * / NOP58 ribonucleoprotein*  / reaction
 ENSDARG00000098349 hdac4 / histone deacetylase 4 / P56524* / Q6NZM9*  / reaction
 ENSDARG00000112483 rnf168 / ring finger protein 168 / Q8IYW5*  / reaction
 ENSDARG00000116835 park7 / Q5XJ36 / parkinson protein 7 / Q99497* / Parkinsonism associated deglycase*  / reaction






 

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