ENSDARG00000070606


Danio rerio

Features
Gene ID: ENSDARG00000070606
  
Biological name :ikbke
  
Synonyms : ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  
Possible biological names infered from orthology : inhibitor of nuclear factor kappa B kinase subunit epsilon / Q14164 / Q9R0T8
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 21364551
Gene end: 21404358
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000074566
Ensembl peptide - ENSDARP00000106309
NCBI entrez gene - 437024     See in Manteia.
RefSeq - NM_001002751
RefSeq Peptide - NP_001002751
swissprot - F1QBC9
ZFIN ID - ZDB-GENE-040718-251
Ensembl - ENSDARG00000070606
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IKBKEENSGALG00000013356Gallus gallus
 IKBKEENSG00000263528Homo sapiens
 IkbkeENSMUSG00000042349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tbk1 / TANK-binding kinase 1 / Q9UHD2*ENSDARG0000010309545
chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSDARG0000001166219
ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSDARG0000007912318
ulk2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSDARG0000009720518
ulk1a / unc-51 like autophagy activating kinase 1a / ULK1* / O75385* / unc-51 like kinase 1* / unc-51 like autophagy activating kinase 1*ENSDARG0000006251817
ulk1b / unc-51 like autophagy activating kinase 1 / ULK1* / O75385* / unc-51 like kinase 1*ENSDARG0000007448117
ulk3 / unc-51 like kinase 3 / Q6PHR2*ENSDARG000001016619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of immune response proteins
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000027777 tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / Q60769* / TNF alpha induced protein 3*  / complex / reaction
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / complex / reaction
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / complex / reaction
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex






 

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