ENSDARG00000022048


Danio rerio

Features
Gene ID: ENSDARG00000022048
  
Biological name :tlr4bb
  
Synonyms : tlr4bb / toll-like receptor 4b, duplicate b
  
Possible biological names infered from orthology : O00206 / Q9QUK6 / TLR4 / toll like receptor 4
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 18523661
Gene end: 18528862
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000028819
NCBI entrez gene - 403132     See in Manteia.
RefSeq - NM_212813
RefSeq Peptide - NP_997978
swissprot - B8A691
ZFIN ID - ZDB-GENE-040219-9
Ensembl - ENSDARG00000022048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLR4ENSGALG00000007001Gallus gallus
 TLR4ENSG00000136869Homo sapiens
 Tlr4ENSMUSG00000039005Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*ENSDARG0000007567166
tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*ENSDARG0000001974263
tlr7 / toll-like receptor 7 / Q9NYK1*ENSDARG0000006881222
tlr21 / toll-like receptor 21ENSDARG0000005804521
tlr22 / toll-like receptor 22ENSDARG0000010404521
tlr3 / toll-like receptor 3 / O15455* / Q99MB1* / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA.*ENSDARG0000001606520
tlr2 / toll-like receptor 2 / O60603*ENSDARG0000003775820
tlr18 / toll-like receptor 18ENSDARG0000004024920
tlr9 / toll-like receptor 9 / Q9NR96* / AC097637.1*ENSDARG0000004449020
tlr5a / toll-like receptor 5a / TLR5* / O60602* / toll like receptor 5*ENSDARG0000004441519
tlr5b / toll-like receptor 5b / TLR5* / O60602* / toll like receptor 5*ENSDARG0000005232219
TLR8 / toll like receptor 8 / Q9NR97*ENSDARG0000010483219
tlr20.2 / tlr20.4 / toll-like receptor 20, tandem duplicate 2 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000008870118
tlr1 / toll-like receptor 1 / TLR6* / TLR10* / Q15399* / Q9BXR5* / Q9EPQ1* / Q9Y2C9* / toll like receptor 6* / toll like receptor 10*ENSDARG0000010064917
tlr19 / toll-like receptor 19 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000007039216
tlr8b / toll-like receptor 8b / TLR8* / Q9NR97* / P58682* / toll like receptor 8*ENSDARG0000007367516
tlr19 / toll-like receptor 19 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000002666315
senp7a / SUMO1/sentrin specific peptidase 7a / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000010952214
senp7a / SUMO1/sentrin specific peptidase 7a / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000011513614
cd180 / CD180 molecule / Q62192* / Q99467* / CD180 antigen *ENSDARG0000009375013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0003341 cilium movement IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation IGI
 biological_processGO:1901534 positive regulation of hematopoietic progenitor cell differentiation IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005929 cilium IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0046696 lipopolysaccharide receptor complex IEA
 molecular_functionGO:0001875 lipopolysaccharide receptor activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of TLR by endogenous ligand
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6-mediated induction of TAK1 complex within TLR4 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm hematopoietic cell decreased amount , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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 ZFA:0009046 T cell T cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000021509 tab2 / Q5RFW2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q9NYJ8* / Q99K90* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex
 ENSDARG00000032639 cd36 / CD36 molecule (thrombospondin receptor) / P16671* / Q08857* / CD36 molecule* / Platelet glycoprotein 4 *  / complex / reaction
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex
 ENSDARG00000062063 tab3 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / complex / reaction
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / complex / reaction
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex






 

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