ENSDARG00000076251


Danio rerio

Features
Gene ID: ENSDARG00000076251
  
Biological name :irf3
  
Synonyms : interferon regulatory factor 3 / irf3
  
Possible biological names infered from orthology : P70671 / Q14653
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 4580372
Gene end: 4598237
  
Corresponding Affymetrix probe sets: Dr.15504.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000126885
Ensembl peptide - ENSDARP00000099633
NCBI entrez gene - 564854     See in Manteia.
RefSeq - NM_001143904
RefSeq Peptide - NP_001137376
swissprot - B7SEE0
ZFIN ID - ZDB-GENE-071120-7
Ensembl - ENSDARG00000076251
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRF3ENSG00000126456Homo sapiens
 Irf3ENSMUSG00000003184Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irf7 / interferon regulatory factor 7 / P70434* / Q92985*ENSDARG0000004566125
irf5 / interferon regulatory factor 5 / P56477* / Q13568*ENSDARG0000004568122
irf6 / interferon regulatory factor 6 / O14896* / P97431*ENSDARG0000010198621
irf4a / interferon regulatory factor 4a / IRF4* / Q15306* / Q64287* / interferon regulatory factor 4*ENSDARG0000000656019
irf10 / interferon regulatory factor 10ENSDARG0000002765819
irf8 / interferon regulatory factor 8 / P23611* / Q02556*ENSDARG0000005640719
irf9 / interferon regulatory factor 9 / Q00978* / Q61179*ENSDARG0000001645718
irf4b / interferon regulatory factor 4b / IRF4* / Q15306* / Q64287* / interferon regulatory factor 4*ENSDARG0000005537416
irf1b / interferon regulatory factor 1b / IRF1* / P10914* / interferon regulatory factor 1*ENSDARG0000004324911
irf1a / interferon regulatory factor 1aENSDARG0000004349211
irf2a / interferon regulatory factor 2aENSDARG0000000738710
irf2 / interferon regulatory factor 2 / P14316* / P23906*ENSDARG000000404659


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IGI


Pathways (from Reactome)
Pathway description
IRF3 mediated activation of type 1 IFN
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / complex / reaction
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex / reaction
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex / reaction
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex / reaction
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex / reaction
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex / reaction
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex / reaction
 ENSDARG00000076302 DTX4 / si:ch211-119e14.2 / Q6PDK8* / Q9Y2E6* / deltex E3 ubiquitin ligase 4* / E3 ubiquitin-protein ligase DTX4 *  / complex / reaction
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / complex / reaction
 ENSDARG00000078016 dtx4 / deltex 4, E3 ubiquitin ligase / Q9Y2E6* / Q6PDK8* / deltex E3 ubiquitin ligase 4* / E3 ubiquitin-protein ligase DTX4 *  / complex / reaction
 ENSDARG00000091058 tmem173 / transmembrane protein 173 / Q3TBT3* / Q86WV6* / Stimulator of interferons protein *  / complex
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex / reaction
 ENSDARG00000101915 pin1 / peptidylprolyl cis/trans isomerase, NIMA-interacting 1 / Q13526*  / complex / reaction






 

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