ENSDARG00000112452


Danio rerio

Features
Gene ID: ENSDARG00000112452
  
Biological name :crebbpb
  
Synonyms : CREB binding protein b / crebbpb
  
Possible biological names infered from orthology : CREB binding protein / CREBBP / Q92793
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 9634777
Gene end: 9722603
  
Corresponding Affymetrix probe sets: Dr.10005.1.A1_at (Zebrafish Array)   Dr.24938.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000140135
NCBI entrez gene - 567111     See in Manteia.
swissprot - A0A0R4IVZ7
ZFIN ID - ZDB-GENE-050302-102
Ensembl - ENSDARG00000112452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CREBBPENSGALG00000007762Gallus gallus
 CREBBPENSG00000005339Homo sapiens
 CrebbpENSMUSG00000022521Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*ENSDARG0000010460969
ep300b / E1A binding protein p300 b / EP300* / Q09472* / B2RWS6* / E1A binding protein p300* / Histone acetyltransferase p300 *ENSDARG0000006110854
ep300a / E1A binding protein p300 a / EP300* / Q09472* / B2RWS6* / E1A binding protein p300* / Histone acetyltransferase p300 *ENSDARG0000010066654
brd4 / F1R5H6 / bromodomain containing 4 / O60885* / Q9ESU6* / Bromodomain-containing protein 4 *ENSDARG000000789049
brd2a / bromodomain containing 2a / BRD2* / Q7JJ13* / P25440* / bromodomain containing 2* / Bromodomain-containing protein 2 *ENSDARG000000222807
brdt / bromodomain, testis-specific / Q91Y44* / Q58F21* / bromodomain testis associated* / Bromodomain testis-specific protein *ENSDARG000001028027
baz2a / bromodomain adjacent to zinc finger domain, 2A / Q9UIF9*ENSDARG000001029747
brd3a / bromodomain containing 3a / BRD3* / Q8K2F0* / Q15059* / bromodomain containing 3* / Bromodomain-containing protein 3 *ENSDARG000000065276
baz2ba / bromodomain adjacent to zinc finger domain, 2Ba / BAZ2B* / Q9UIF8* / bromodomain adjacent to zinc finger domain 2B*ENSDARG000000577826
brd3b / bromodomain containing 3b / BRD3* / Q8K2F0* / Q15059* / bromodomain containing 3* / Bromodomain-containing protein 3 *ENSDARG000001001296
baz1a / bromodomain adjacent to zinc finger domain, 1A / O88379* / Q9NRL2* / Bromodomain adjacent to zinc finger domain protein 1A *ENSDARG000000997454
baz1b / bromodomain adjacent to zinc finger domain, 1B / Q9UIG0* / Q9Z277* / Tyrosine-protein kinase BAZ1B *ENSDARG000001028324
brd2b / bromodomain containing 2bENSDARG000000460872
baz1a / bromodomain adjacent to zinc finger domain, 1A / O88379* / Q9NRL2* / Bromodomain adjacent to zinc finger domain protein 1A *ENSDARG000000632331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000197  Zinc finger, TAZ-type
 IPR000433  Zinc finger, ZZ-type
 IPR001487  Bromodomain
 IPR003101  Coactivator CBP, KIX domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010303  CREB-binding protein/p300, atypical RING domain
 IPR013178  Histone acetyltransferase Rtt109/CBP
 IPR014744  Nuclear receptor coactivator, CREB-bp-like, interlocking
 IPR018359  Bromodomain, conserved site
 IPR031162  CBP/p300-type histone acetyltransferase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016573 histone acetylation IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Formation of the beta-catenin:TCF transactivating complex
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Attenuation phase
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
CD209 (DC-SIGN) signaling
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX3 regulates NOTCH signaling
Estrogen-dependent gene expression
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008697 epas1a / endothelial PAS domain protein 1a / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / complex
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex / reaction
 ENSDARG00000031894 lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*  / complex / reaction
 ENSDARG00000021855 arnt / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*  / complex
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / complex
 ENSDARG00000059279 tfap2a / transcription factor AP-2 alpha / P05549*  / complex / reaction
 ENSDARG00000070794 greb1 / growth regulation by estrogen in breast cancer 1 / Q3UHK3* / Q4ZG55* / Protein GREB1 *  / complex / reaction
 ENSDARG00000057671 epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / complex
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / complex / reaction
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / complex / reaction
 ENSDARG00000087646 runx1 / runt-related transcription factor 1 / Q01196*  / complex / reaction
 ENSDARG00000040606 tfap2c / transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) / Q61312* / Q92754* / transcription factor AP-2 gamma*  / complex / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSDARG00000100826 hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*  / complex
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / complex / reaction
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / reaction
 ENSDARG00000101009 cited4b / Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b / Q9WUL8* / CITED4* / Q96RK1* / Cbp/p300-interacting transactivator 4 * / Cbp/p300 interacting t...  / complex / reaction






 

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