ENSDARG00000008818


Danio rerio

Features
Gene ID: ENSDARG00000008818
  
Biological name :hsf1
  
Synonyms : heat shock transcription factor 1 / hsf1
  
Possible biological names infered from orthology : heat shock factor 1 / P38532 / Q00613
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 3056450
Gene end: 3082268
  
Corresponding Affymetrix probe sets: Dr.8301.1.S1_a_at (Zebrafish Array)   Dr.8301.4.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000076789
Ensembl peptide - ENSDARP00000121268
NCBI entrez gene - 58123     See in Manteia.
swissprot - F6P697
swissprot - Q1LXV0
ZFIN ID - ZDB-GENE-000616-16
Ensembl - ENSDARG00000008818
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSF1ENSG00000185122Homo sapiens
 Hsf1ENSMUSG00000022556Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hsf2 / heat shock transcription factor 2 / Q03933*ENSDARG0000005309732
hsf4 / heat shock transcription factor 4 / Q9R0L1* / Q9ULV5* / Heat shock factor protein 4 *ENSDARG0000001325128
si:dkey-18a10.3ENSDARG0000009081426


Protein motifs (from Interpro)
Interpro ID Name
 IPR000232  Heat shock factor (HSF)-type, DNA-binding
 IPR010542  Vertebrate heat shock transcription factor, C-terminal domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR027725  Heat shock transcription factor family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009408 response to heat IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain absent , abnormal
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 ZFA:0000035 lens lens structure , abnormal
lens decreased size , abnormal
lens immature , abnormal
lens decreased circumference , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye decreased diameter , abnormal
eye decreased circumference , abnormal
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 ZFA:0000152 retina retina structure , abnormal
retina decreased size , abnormal
retina disorganized , abnormal
retina absent , abnormal
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 ZFA:0001283 pupil pupil decreased diameter , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018530 mapkapk2b / mitogen-activated protein kinase-activated protein kinase 2b / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...  / reaction
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex / reaction
 ENSDARG00000008447 fkbp4 / FK506 binding protein 4 / P30416* / Q02790* / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed*  / complex / reaction
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction
 ENSDARG00000002552 mapkapk2a / mitogen-activated protein kinase-activated protein kinase 2a / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...  / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000043010 Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...  / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction
 ENSDARG00000006399 ywhae1 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 / YWHAE* / P62259* / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase act...  / complex / reaction
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / complex / reaction
 ENSDARG00000041921 hsbp1b / heat shock factor binding protein 1b / HSBP1* / O75506* / Q9CQZ1* / heat shock factor binding protein 1*  / complex / reaction
 ENSDARG00000037284 ptges3a / prostaglandin E synthase 3a (cytosolic) / PTGES3* / Q9R0Q7* / Q15185* / prostaglandin E synthase 3*  / complex / reaction
 ENSDARG00000068064 sirt1 / sirtuin 1 / Q96EB6*  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / reaction
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / reaction






 

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