ENSDARG00000002552


Danio rerio

Features
Gene ID: ENSDARG00000002552
  
Biological name :mapkapk2a
  
Synonyms : mapkapk2a / mitogen-activated protein kinase-activated protein kinase 2a
  
Possible biological names infered from orthology : MAPKAPK2 / MAP kinase-activated protein kinase 2 / mitogen-activated protein kinase-activated protein kinase 2 / P49137 / P49138
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 21154678
Gene end: 21218172
  
Corresponding Affymetrix probe sets: Dr.20395.1.A1_at (Zebrafish Array)   Dr.25777.1.S1_at (Zebrafish Array)   NM_201303_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000020470
NCBI entrez gene - 327321     See in Manteia.
RefSeq - NM_201303
RefSeq Peptide - NP_958460
swissprot - Q7T2F2
ZFIN ID - ZDB-GENE-030131-5532
Ensembl - ENSDARG00000002552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPKAPK2ENSGALG00000000883Gallus gallus
 P49137ENSG00000162889Homo sapiens
 P49138ENSMUSG00000016528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mapkapk3 / mitogen-activated protein kinase-activated protein kinase 3 / Q16644*ENSDARG0000011161270
mapkapk2b / mitogen-activated protein kinase-activated protein kinase 2b / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...ENSDARG0000001853069
mapkapk5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41*ENSDARG0000002808241
mknk2b / MAP kinase interacting serine/threonine kinase 2b / MKNK2* / Q8CDB0* / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2* / MAP kinase-interacting serine/threonine-protein...ENSDARG0000001516430
mknk2a / MAP kinase interacting serine/threonine kinase 2a / MKNK2* / Q8CDB0* / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2* / MAP kinase-interacting serine/threonine-protein...ENSDARG0000001137329
mknk1 / MAP kinase interacting serine/threonine kinase 1 / Q9BUB5*ENSDARG0000001841129


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IBA
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0055113 epiboly involved in gastrulation with mouth forming second IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IMP
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
p38MAPK events
CREB phosphorylation
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Oxidative Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk quality , abnormal
yolk broken , abnormal
yolk constricted , abnormal
Show

 ZFA:0000712 I-YSL I-YSL nucleus aggregated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000045836 mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex / reaction
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / complex / reaction
 ENSDARG00000021443 zfp36l1b / zinc finger protein 36, C3H type-like 1b / Q07352* / P23950* / ZFP36L1* / ZFP36 ring finger protein like 1* / zinc finger protein 36, C3H type-like 1*  / reaction
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / complex / reaction
 ENSDARG00000016154 zfp36l1a / zinc finger protein 36, C3H type-like 1a / Q07352* / P23950* / ZFP36L1* / ZFP36 ring finger protein like 1* / zinc finger protein 36, C3H type-like 1*  / reaction
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / reaction
 ENSDARG00000099184 map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction






 

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