ENSDARG00000045836


Danio rerio

Features
Gene ID: ENSDARG00000045836
  
Biological name :mapk11
  
Synonyms : mapk11 / mitogen-activated protein kinase 11
  
Possible biological names infered from orthology : Q15759 / Q9WUI1
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 5506946
Gene end: 5522437
  
Corresponding Affymetrix probe sets: Dr.21717.1.A1_at (Zebrafish Array)   NM_001002095_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000034350
Ensembl peptide - ENSDARP00000125281
Ensembl peptide - ENSDARP00000136821
NCBI entrez gene - 415185     See in Manteia.
RefSeq - NM_001002095
RefSeq Peptide - NP_001002095
swissprot - H0WEK3
swissprot - A0A0R4IRM9
swissprot - I3VB58
swissprot - Q6IQ84
ZFIN ID - ZDB-GENE-040625-75
Ensembl - ENSDARG00000045836
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK11ENSGALG00000040023Gallus gallus
 MAPK11ENSG00000185386Homo sapiens
 Mapk11ENSMUSG00000053137Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*ENSDARG0000002872173
Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*ENSDARG0000000085771
mapk12b / mitogen-activated protein kinase 12b / P53778* / MAPK12* / O08911* / mitogen-activated protein kinase 12*ENSDARG0000000640958
mapk13 / mitogen-activated protein kinase 13ENSDARG0000005847058
O42376 / mapk12a / mitogen-activated protein kinase 12a / O08911* / MAPK12* / P53778* / mitogen-activated protein kinase 12*ENSDARG0000004202157
zgc:171775ENSDARG0000005838155
mapk8a / mitogen-activated protein kinase 8aENSDARG0000003188848
mapk10 / mitogen-activated protein kinase 10 / P53779* / mitogen-activated protein kinase 10 isoform 1x *ENSDARG0000010273048
mapk9 / mitogen-activated protein kinase 9 / P45984* / Q9WTU6*ENSDARG0000007736447
mapk8b / Q9DGD9 / mitogen-activated protein kinase 8bENSDARG0000000987046
BX324164.5 / MAPK13* / O15264* / mitogen-activated protein kinase 13*ENSDARG0000011014324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Oxidative Stress Induced Senescence
CDO in myogenesis
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018530 mapkapk2b / mitogen-activated protein kinase-activated protein kinase 2b / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...  / complex / reaction
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex
 ENSDARG00000009418 mef2cb / myocyte enhancer factor 2cb / MEF2C* / Q8CFN5* / Q06413* / myocyte enhancer factor 2C* / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA.*  / complex / reaction
 ENSDARG00000002552 mapkapk2a / mitogen-activated protein kinase-activated protein kinase 2a / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...  / complex / reaction
 ENSDARG00000023903 atf2 / activating transcription factor 2 / P15336* / P16951* / Cyclic AMP-dependent transcription factor ATF-2 *  / reaction
 ENSDARG00000013397 bnip2 / BCL2 interacting protein 2 / O54940* / Q12982* / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 *  / complex
 ENSDARG00000060551 rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / Q8C050* / ribosomal protein S6 kinase A5*  / reaction
 ENSDARG00000061328 cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / reaction
 ENSDARG00000068191 cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*  / complex
 ENSDARG00000024785 B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...  / complex
 ENSDARG00000028082 mapkapk5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41*  / complex
 ENSDARG00000035187 abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex
 ENSDARG00000105345 zgc:173552  / reaction
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / reaction
 ENSDARG00000102441 ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*  / complex
 ENSDARG00000099184 map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction






 

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