ENSDARG00000044573


Danio rerio

Features
Gene ID: ENSDARG00000044573
  
Biological name :cdc42
  
Synonyms : cdc42 / cell division cycle 42
  
Possible biological names infered from orthology : Cell division control / P60766 / P60953
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 39120306
Gene end: 39148199
  
Corresponding Affymetrix probe sets: Dr.26344.2.S1_a_at (Zebrafish Array)   Dr.26344.3.S1_at (Zebrafish Array)   Dr.26344.3.S1_a_at (Zebrafish Array)   Dr.4697.2.A1_at (Zebrafish Array)   NM_001018120_at (Zebrafish Genome Array with custom cdf files)   NM_200632_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000129339
Ensembl peptide - ENSDARP00000129719
Ensembl peptide - ENSDARP00000149720
Ensembl peptide - ENSDARP00000155235
NCBI entrez gene - 336839     See in Manteia.
RefSeq - NM_200632
RefSeq - NM_001018120
RefSeq Peptide - NP_001018130
RefSeq Peptide - NP_956926
swissprot - Q52WY2
swissprot - Q6PFU4
ZFIN ID - ZDB-GENE-030131-8783
Ensembl - ENSDARG00000044573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDC42ENSGALG00000004796Gallus gallus
 CDC42ENSG00000070831Homo sapiens
 Cdc42ENSMUSG00000006699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdc42l / cell division cycle 42, likeENSDARG0000004015891
cdc42l2 / cell division cycle 42 like 2ENSDARG0000005786977
rac1b / Rac family small GTPase 1b / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000008795471
rac3b / Rac family small GTPase 3b / RAC3* / P60764* / P60763* / Rac family small GTPase 3* / RAS-related C3 botulinum substrate 3*ENSDARG0000002079570
rac1a / Rac family small GTPase 1a / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000007484970
rac3a / Rac family small GTPase 3a / RAC3* / P60763* / Rac family small GTPase 3*ENSDARG0000009006270
rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *ENSDARG0000003801068
rhoq / ras homolog family member Q / P17081* / Q8R527* / Rho-related GTP-binding protein RhoQ *ENSDARG0000002595367
rhogc / ras homolog gene family, member GcENSDARG0000002840163
rhoj / ras homolog family member J / Q9ER71* / Q9H4E5*ENSDARG0000002025062
rhogb / ras homolog family member Gb / RHOG* / P84095* / P84096* / ras homolog family member G*ENSDARG0000000430161
si:ch211-1f22.1 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000001320361
rhoga / ras homolog family member Ga / RHOG* / P84095* / P84096* / ras homolog family member G*ENSDARG0000006865361
rhogd / ras homolog gene family, member GdENSDARG0000003060860
rac1l / Rac family small GTPase 1, like / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000005464959
rhoua / ras homolog family member Ua / RHOU* / Q9EQT3* / Q7L0Q8* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *ENSDARG0000001970958
si:ch211-1f22.2 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000009666658
RHOU (1 of many) / si:ch211-133l11.10 / RHOU* / Q9EQT3* / Q7L0Q8* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *ENSDARG0000000562654
rhoub / ras homolog family member UbENSDARG0000001296853
rhov / ras homolog family member V / Q8VDU1* / Q96L33* / Rho-related GTP-binding protein RhoV *ENSDARG0000007043449


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0038189 neuropilin signaling pathway IMP
 biological_processGO:0042051 compound eye photoreceptor development IMP
 biological_processGO:0042074 cell migration involved in gastrulation IGI
 biological_processGO:0042461 photoreceptor cell development IMP
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060271 cilium assembly IGI
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
EGFR downregulation
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
G alpha (12/13) signalling events
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer apoptotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer apoptotic , abnormal
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 ZFA:0000150 pronephric duct pronephric duct cilium disorganized , abnormal
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 ZFA:0000152 retina retina decreased size , abnormal
retina cell decreased amount , abnormal
retina apoptotic , abnormal
retina apoptotic process increased occurrence , abnormal
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 ZFA:0001058 caudal fin caudal fin curved , abnormal
caudal fin decreased length , abnormal
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 ZFA:0001286 caudal vein plexus caudal vein plexus has fewer parts of type endothelial cell , abnormal
caudal vein plexus sprouting angiogenesis process quality , abnormal
caudal vein plexus angiogenic sprout decreased amount , abnormal
caudal vein plexus blood vessel endothelial cell has fewer parts of type blood vessel endothelial cell filopodium, abnormal
caudal vein plexus decreased width , abnormal
caudal vein plexus malformed , abnormal
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 ZFA:0001287 renal tubule renal tubule dilated , abnormal
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 ZFA:0001288 renal glomerulus renal glomerulus disorganized , abnormal
renal glomerulus distended , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer decreased thickness , abnormal
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 ZFA:0009127 photoreceptor cell photoreceptor cell photoreceptor outer segment absent , abnormal
photoreceptor cell photoreceptor outer segment morphology , abnormal
photoreceptor cell photoreceptor outer segment decreased length , abnormal
photoreceptor cell photoreceptor outer segment decreased amount , abnormal
photoreceptor cell photoreceptor inner segment absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000009796 klc1a / kinesin light chain 1a / KLC1* / Q07866* / AL139300.1* / kinesin light chain 1* / kinesin light chain 1 isoform 1G *  / complex / reaction
 ENSDARG00000007723 efnb1 / ephrin-B1 / P52795* / P98172*  / complex
 ENSDARG00000032802 ktn1 / kinectin 1 / Q86UP2*  / complex / reaction
 ENSDARG00000042021 O42376 / mapk12a / mitogen-activated protein kinase 12a / O08911* / MAPK12* / P53778* / mitogen-activated protein kinase 12*  / complex
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex
 ENSDARG00000045836 mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSDARG00000006409 mapk12b / mitogen-activated protein kinase 12b / P53778* / MAPK12* / O08911* / mitogen-activated protein kinase 12*  / complex
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000022531 ntn1b / netrin 1b / NTN1* / O09118* / O95631* / netrin 1*  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSDARG00000073848 arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex / reaction
 ENSDARG00000021539 ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex
 ENSDARG00000020164 efnb2a / O73874 / ephrin-B2a / EFNB2* / P52799* / P52800* / ephrin B2*  / complex
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex
 ENSDARG00000037746 actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000042277 efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*  / complex
 ENSDARG00000060010 iqgap2 / IQ motif containing GTPase activating protein 2 / Q13576* / Q3UQ44* / Ras GTPase-activating-like protein IQGAP2 *  / complex / reaction
 ENSDARG00000019426 trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*  / complex / reaction
 ENSDARG00000037870 actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000013397 bnip2 / BCL2 interacting protein 2 / O54940* / Q12982* / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 *  / complex
 ENSDARG00000074050 efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*  / complex
 ENSDARG00000061328 cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000068191 cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*  / complex
 ENSDARG00000024785 B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...  / complex
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000006299 arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / complex / reaction
 ENSDARG00000076757 ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex
 ENSDARG00000112993 efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*  / complex
 ENSDARG00000035187 abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSDARG00000015149 wasa / Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a / WAS* / P70315* / P42768* / Wiskott-Aldrich syndrome*  / complex
 ENSDARG00000045298 wipf2a / WAS/WASL interacting protein family, member 2a / WIPF2* / Q6PEV3* / Q8TF74* / WAS/WASL interacting protein family member 2*  / reaction
 ENSDARG00000071084 wipf1b / WAS/WASL interacting protein family, member 1b / WIPF1* / O43516* / Q8K1I7* / WAS/WASL interacting protein family member 1*  / reaction
 ENSDARG00000079475 nckipsd / NCK interacting protein with SH3 domain / Q9NZQ3*  / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000104300 wipf1a / WAS/WASL interacting protein family, member 1a / WIPF1* / O43516* / Q8K1I7* / WAS/WASL interacting protein family member 1*  / reaction
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex / reaction
 ENSDARG00000037373 ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex
 ENSDARG00000098936 kif5aa / kinesin family member 5A, a / KIF5A* / Q12840* / kinesin family member 5A*  / complex / reaction
 ENSDARG00000105112 ntn1a / netrin 1a / NTN1* / O09118* / O95631* / netrin 1*  / complex / reaction
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / complex / reaction
 ENSDARG00000102441 ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*  / complex






 

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