ENSDARG00000052739


Danio rerio

Features
Gene ID: ENSDARG00000052739
  
Biological name :egf
  
Synonyms : egf / epidermal growth factor
  
Possible biological names infered from orthology : Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01132 / P01133
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 36279826
Gene end: 36325558
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000069126
Ensembl peptide - ENSDARP00000111809
Ensembl peptide - ENSDARP00000142359
NCBI entrez gene - 403045     See in Manteia.
RefSeq - NM_205731
RefSeq Peptide - NP_991294
swissprot - F1QGQ2
swissprot - A0A140LGI0
swissprot - F1QKU8
ZFIN ID - ZDB-GENE-070922-1
Ensembl - ENSDARG00000052739
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EGFENSGALG00000012155Gallus gallus
 EGFENSG00000138798Homo sapiens
 EgfENSMUSG00000028017Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nid1b / nidogen 1b / NID1* / P14543* / P10493* / nidogen 1*ENSDARG0000010312916
nid1a / nidogen 1a / NID1* / P14543* / P10493* / nidogen 1*ENSDARG0000006871014
nid2b / nidogen 2b (osteonidogen) / NID2* / Q14112* / O88322* / nidogen 2*ENSDARG0000000947113
nid2a / nidogen 2a (osteonidogen) / NID2* / Q14112* / O88322* / nidogen 2*ENSDARG0000007570713
si:dkey-258f14.3ENSDARG000000759749
si:dkey-258f14.7ENSDARG000000959255


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR016317  Pro-epidermal growth factor
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
PIP3 activates AKT signaling
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000180 caudal vein caudal vein blood circulation absent , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage hypoplastic , abnormal
Meckels cartilage aplastic , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel blood circulation absent , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage hypoplastic , abnormal
ceratobranchial cartilage aplastic , abnormal
Show

 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel blood circulation absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000078308 spry2 / sprouty RTK signaling antagonist 2 / O43597* / Q9QXV8*  / complex
 ENSDARG00000073848 arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex
 ENSDARG00000078216 eps15 / epidermal growth factor receptor pathway substrate 15 / P42566* / P42567* / Epidermal growth factor receptor substrate 15 *  / complex / reaction
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / reaction
 ENSDARG00000006299 arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex
 ENSDARG00000010411 epn1 / epsin 1 / Q80VP1* / Q9Y6I3*  / complex / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex
 ENSDARG00000008377 epn2 / epsin 2 / O95208* / Q8CHU3*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex
 ENSDARG00000103985 spry1 / sprouty homolog 1, antagonist of FGF signaling (Drosophila) / O43609* / sprouty RTK signaling antagonist 1*  / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex
 ENSDARG00000076768 reps2 / RALBP1 associated Eps domain containing 2 / Q8NFH8*  / complex






 

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