ENSDARG00000105276


Danio rerio

Features
Gene ID: ENSDARG00000105276
  
Biological name :grb2a
  
Synonyms : grb2a / growth factor receptor-bound protein 2a
  
Possible biological names infered from orthology : GRB2 / growth factor receptor bound protein 2 / P62993 / Q60631
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 19344749
Gene end: 19381993
  
Corresponding Affymetrix probe sets: Dr.20787.1.A1_at (Zebrafish Array)   Dr.20787.2.A1_a_at (Zebrafish Array)   NM_001007769_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000139535
Ensembl peptide - ENSDARP00000151370
Ensembl peptide - ENSDARP00000133720
NCBI entrez gene - 493609     See in Manteia.
RefSeq - NM_001007769
RefSeq Peptide - NP_001007770
swissprot - A0A0R4IWL3
swissprot - Q5RKN6
ZFIN ID - ZDB-GENE-041121-1
Ensembl - ENSDARG00000105276
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRB2ENSGALG00000008016Gallus gallus
 GRB2ENSG00000177885Homo sapiens
 Grb2ENSMUSG00000059923Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*ENSDARG0000003805994
grapb / GRB2-related adaptor protein b / GRAP* / GRAPL* / Q9CX99* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2-related adapter protein * / GRB2 related adaptor protein like*ENSDARG0000002266852
grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*ENSDARG0000000646851
grapa / GRB2-related adaptor protein a / GRAP* / GRAPL* / Q9CX99* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2-related adapter protein * / GRB2 related adaptor protein like*ENSDARG0000000541450
grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*ENSDARG0000010116947
nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *ENSDARG0000001820625
nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *ENSDARG0000004336125
nck1a / NCK adaptor protein 1a / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *ENSDARG0000007426225
nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *ENSDARG0000007536925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR030219  Growth factor receptor-bound protein 2
 IPR035641  GRB2, N-terminal SH3 domain
 IPR035643  GRB2, C-terminal SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA


Pathways (from Reactome)
Pathway description
FCERI mediated Ca+2 mobilization
MET activates RAP1 and RAC1
FCERI mediated MAPK activation
EGFR Transactivation by Gastrin
Signalling to RAS
Insulin receptor signalling cascade
PI3K Cascade
Negative regulation of FGFR1 signaling
MET receptor recycling
SHC-mediated cascade:FGFR4
MET activates PI3K/AKT signaling
SOS-mediated signalling
Negative regulation of FGFR3 signaling
GRB2 events in ERBB2 signaling
Cargo recognition for clathrin-mediated endocytosis
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SHC-mediated cascade:FGFR2
Clathrin-mediated endocytosis
FRS-mediated FGFR3 signaling
Signaling by SCF-KIT
GRB2 events in EGFR signaling
Negative regulation of FGFR4 signaling
Costimulation by the CD28 family
PIP3 activates AKT signaling
RHO GTPases Activate WASPs and WAVEs
PI3K events in ERBB2 signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Negative regulation of FGFR2 signaling
FRS-mediated FGFR4 signaling
PI-3K cascade:FGFR1
GRB2:SOS provides linkage to MAPK signaling for Integrins
Activated NTRK2 signals through FRS2 and FRS3
DAP12 signaling
Downstream signal transduction
EGFR downregulation
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
GAB1 signalosome
Interleukin-15 signaling
Interleukin receptor SHC signaling
MET activates PTPN11
MET activates RAS signaling
NTRK2 activates RAC1
Negative regulation of MET activity
NCAM signaling for neurite out-growth
PI-3K cascade:FGFR4
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
RET signaling
RAF/MAP kinase cascade
Regulation of signaling by CBL
Regulation of KIT signaling
Regulation of actin dynamics for phagocytic cup formation
SHC1 events in EGFR signaling
SHC-related events triggered by IGF1R
SHC1 events in ERBB4 signaling
Signal attenuation
SHC-mediated cascade:FGFR3
SHC-mediated cascade:FGFR1
Role of LAT2/NTAL/LAB on calcium mobilization
Tie2 Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017565 itk / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *  / complex
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / reaction
 ENSDARG00000007356 fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / complex / reaction
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000043317 kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000004782 fgfr3 / fibroblast growth factor receptor 3 / P22607*  / complex / reaction
 ENSDARG00000015752 zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*  / reaction
 ENSDARG00000005318 stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2*  / complex / reaction
 ENSDARG00000006468 grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / complex / reaction
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000056133 kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000001769 ptpra / protein tyrosine phosphatase, receptor type, A / P18052* / P18433*  / reaction / complex
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex / reaction
 ENSDARG00000028699 crkl / v-crk avian sarcoma virus CT10 oncogene homolog-like / P46109* / P47941* / Crk-like protein * / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000015149 wasa / Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a / WAS* / P70315* / P42768* / Wiskott-Aldrich syndrome*  / reaction
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / complex / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex
 ENSDARG00000042723 gfra2a / GDNF family receptor alpha 2a / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSDARG00000043962 fgf18b / fibroblast growth factor 18b / FGF18* / O89101* / O76093* / fibroblast growth factor 18*  / complex / reaction
 ENSDARG00000052928 arf6b / ADP-ribosylation factor 6b / ARF6* / P62330* / P62331* / ADP ribosylation factor 6*  / complex
 ENSDARG00000068763 plcg2 / phospholipase C, gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000058503 flt3 / fms-related tyrosine kinase 3 / P36888*  / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000044015 gfra2b / GDNF family receptor alpha 2b / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSDARG00000055305 ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...  / complex / reaction
 ENSDARG00000028663 tek / TEK tyrosine kinase, endothelial / Q02763* / TEK receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000045298 wipf2a / WAS/WASL interacting protein family, member 2a / WIPF2* / Q6PEV3* / Q8TF74* / WAS/WASL interacting protein family member 2*  / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / complex / reaction
 ENSDARG00000076294 klb / klotho beta / Q86Z14* / Q99N32* / Beta-klotho *  / complex / reaction
 ENSDARG00000079849 nrtn / neurturin / P97463* / Q99748*  / complex / reaction
 ENSDARG00000074582 gfra4b / GDNF family receptor alpha 4b / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / complex / reaction
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / complex / reaction
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction
 ENSDARG00000078216 eps15 / epidermal growth factor receptor pathway substrate 15 / P42566* / P42567* / Epidermal growth factor receptor substrate 15 *  / complex / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000079862 kl / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / complex / reaction
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000071084 wipf1b / WAS/WASL interacting protein family, member 1b / WIPF1* / O43516* / Q8K1I7* / WAS/WASL interacting protein family member 1*  / reaction
 ENSDARG00000019231 sptan1 / spectrin alpha, non-erythrocytic 1 / SPTA1* / Q13813* / P08032* / P16546* / P02549* / spectrin alpha, erythrocytic 1* / Spectrin alpha chain, erythrocytic 1 * / Spectrin alpha chai...  / reaction / complex
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / complex / reaction
 ENSDARG00000076768 reps2 / RALBP1 associated Eps domain containing 2 / Q8NFH8*  / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000069105 fgfr4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000087704 gfra3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSDARG00000086070 fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / complex / reaction
 ENSDARG00000020960 hgs / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex / reaction
 ENSDARG00000089043 ptpn6 / protein tyrosine phosphatase, non-receptor type 6 / P29350* / P29351*  / complex / reaction
 ENSDARG00000062080 shc2 / SHC (Src homology 2 domain containing) transforming protein 2 / P98077* / Q8BMC3* / SHC adaptor protein 2*  / complex / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000002127 stam / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / P70297* / Q92783* / signal transducing adaptor molecule*  / complex / reaction
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / complex / reaction
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSDARG00000004433 btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *  / complex / reaction
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / complex / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / reaction / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSDARG00000039959 gdnfa / glial cell derived neurotrophic factor a / GDNF* / P39905* / P48540* / glial cell derived neurotrophic factor* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), tra...  / complex / reaction
 ENSDARG00000098477 tec / tec protein tyrosine kinase / P42680*  / complex
 ENSDARG00000101169 grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / complex / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000018817 bdnf / brain-derived neurotrophic factor / P21237* / P23560*  / complex
 ENSDARG00000073848 arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex
 ENSDARG00000078308 spry2 / sprouty RTK signaling antagonist 2 / O43597* / Q9QXV8*  / complex
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSDARG00000059897 ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSDARG00000053404 PPP2CA / zgc:56064 / P67775* / P63330* / protein phosphatase 2 catalytic subunit alpha* / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform *  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / complex / reaction
 ENSDARG00000006299 arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex
 ENSDARG00000010411 epn1 / epsin 1 / Q80VP1* / Q9Y6I3*  / complex / reaction
 ENSDARG00000008377 epn2 / epsin 2 / O95208* / Q8CHU3*  / complex / reaction
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000099241 ppp2cb / protein phosphatase 2, catalytic subunit, beta isozyme / P62715* / P62714* / protein phosphatase 2 catalytic subunit beta* / Serine/threonine-protein phosphatase 2A catalytic subun...  / complex
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction
 ENSDARG00000098511 ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000098871 GGA3 (1 of many) / si:ch73-157i16.3 / GGA3* / Q9NZ52* / Q8BMI3* / ADP-ribosylation factor-binding protein GGA3 * / golgi associated, gamma adaptin ear containing, ARF binding protein 3*  / complex
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000098663 fgf19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / complex / reaction
 ENSDARG00000105120 gab2 / GRB2-associated binding protein 2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein family member 4*  / complex / reaction
 ENSDARG00000102778 fgf17 / Q6SJP8 / fibroblast growth factor 17 / O60258* / P63075*  / complex / reaction
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / complex / reaction
 ENSDARG00000102525 lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction
 ENSDARG00000104300 wipf1a / WAS/WASL interacting protein family, member 1a / WIPF1* / O43516* / Q8K1I7* / WAS/WASL interacting protein family member 1*  / reaction
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / complex / reaction
 ENSDARG00000105033 BX897691.1 / BTLA* / Q7Z6A9* / B and T lymphocyte associated*  / complex / reaction






 

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