ENSDARG00000055305


Danio rerio

Features
Gene ID: ENSDARG00000055305
  
Biological name :ret
  
Synonyms : ret / ret proto-oncogene receptor tyrosine kinase
  
Possible biological names infered from orthology : P07949 / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / ret proto-oncogene
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 25584556
Gene end: 25632756
  
Corresponding Affymetrix probe sets: Dr.17711.1.S1_at (Zebrafish Array)   Dr.23453.1.S1_s_at (Zebrafish Array)   NM_181662_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000072093
Ensembl peptide - ENSDARP00000116296
NCBI entrez gene - 30512     See in Manteia.
RefSeq - NM_181662
RefSeq Peptide - NP_858048
swissprot - F1R376
swissprot - A8E7C6
ZFIN ID - ZDB-GENE-980526-307
Ensembl - ENSDARG00000055305
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RETENSGALG00000002555Gallus gallus
 RETENSG00000165731Homo sapiens
 RetENSMUSG00000030110Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...ENSDARG0000007049421
flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSDARG0000010445321
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732120
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811520
pdgfrb / platelet-derived growth factor receptor, beta polypeptide / P09619* / platelet derived growth factor receptor beta*ENSDARG0000010089720
kdrl / kinase insert domain receptor likeENSDARG0000010521520
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478219
fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*ENSDARG0000001102719
flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*ENSDARG0000001937119
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613319
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910519
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119018
kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000004331718
csf1ra / colony stimulating factor 1 receptor, a / CSF1R* / P09581* / P07333* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSDARG0000010298618
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362417
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002126  Cadherin
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015919  Cadherin-like
 IPR016249  Tyrosine-protein kinase, Ret receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0014707 branchiomeric skeletal muscle development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0072114 pronephros morphogenesis IMP
 biological_processGO:1901166 neural crest cell migration involved in autonomic nervous system development IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder absent , abnormal
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 ZFA:0000112 gut gut distal region lacks all parts of type enteric neuron , abnormal
gut neuron neural crest derived absent , abnormal
gut innervation disrupted , abnormal
gut neuron neural crest derived decreased distribution , abnormal
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 ZFA:0000151 pronephros pronephros decreased length , abnormal
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 ZFA:0000462 abductor hyohyoid abductor hyohyoid has fewer parts of type skeletal muscle cell , abnormal
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 ZFA:0000465 adductor operculi adductor operculi has fewer parts of type skeletal muscle cell , abnormal
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 ZFA:0000498 dilator operculi dilator operculi has fewer parts of type skeletal muscle cell , abnormal
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 ZFA:0000537 levator operculi levator operculi has fewer parts of type skeletal muscle cell , abnormal
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 ZFA:0000547 mouth mouth closed , abnormal
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 ZFA:0000706 posterior intestine posterior intestine neuron absent , abnormal
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 ZFA:0000715 adductor hyohyoid adductor hyohyoid has fewer parts of type skeletal muscle cell , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast increased amount , abnormal
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 ZFA:0001155 enteric nervous system enteric nervous system decreased distribution , abnormal
enteric nervous system neuron decreased amount , abnormal
enteric nervous system absent , abnormal
enteric nervous system neuron absent , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium neuron projection absent , abnormal
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 ZFA:0001338 intestine intestine peristalsis decreased process quality , abnormal
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 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 malformed , abnormal
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 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule morphology , abnormal
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 ZFA:0005775 enteric neuron enteric neuron decreased amount , abnormal
enteric neuron absent , abnormal
enteric neuron decreased amount , exacerbated
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 ZFA:0009238 afferent neuron afferent neuron truncated , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex
 ENSDARG00000002013 grb10a / growth factor receptor-bound protein 10a / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction
 ENSDARG00000042723 gfra2a / GDNF family receptor alpha 2a / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000063032 dok6 / docking protein 6 / Q2MHE5* / Q6PKX4*  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex
 ENSDARG00000044015 gfra2b / GDNF family receptor alpha 2b / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000055305 ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...  / complex / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000053272 si:dkey-166d12.2 / P47736* / RAP1GAP* / RAP1 GTPase activating protein*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000079849 nrtn / neurturin / P97463* / Q99748*  / complex / reaction
 ENSDARG00000074582 gfra4b / GDNF family receptor alpha 4b / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000073731 dok4 / docking protein 4 / Q8TEW6* / Q99KE3*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000087704 gfra3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSDARG00000078108 dok1a / docking protein 1a / DOK1* / P97465* / Q99704* / docking protein 1*  / complex / reaction
 ENSDARG00000035308 grb10b / growth factor receptor-bound protein 10b / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000039959 gdnfa / glial cell derived neurotrophic factor a / GDNF* / P39905* / P48540* / glial cell derived neurotrophic factor* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), tra...  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000105120 gab2 / GRB2-associated binding protein 2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein family member 4*  / complex






 

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