ENSDARG00000035308


Danio rerio

Features
Gene ID: ENSDARG00000035308
  
Biological name :grb10b
  
Synonyms : grb10b / growth factor receptor-bound protein 10b
  
Possible biological names infered from orthology : GRB10 / growth factor receptor bound protein 10 / Q13322 / Q60760
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 8364085
Gene end: 8520474
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000122780
NCBI entrez gene - 562032     See in Manteia.
RefSeq - XM_009292073
RefSeq - XM_685427
swissprot - F1QSC3
ZFIN ID - ZDB-GENE-091020-12
Ensembl - ENSDARG00000035308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRB10ENSGALG00000013100Gallus gallus
 GRB10ENSG00000106070Homo sapiens
 Grb10ENSMUSG00000020176Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grb10a / growth factor receptor-bound protein 10a / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*ENSDARG0000000201377
si:ch211-253b1.3 / GRB7* / Q03160* / Q14451* / growth factor receptor bound protein 7*ENSDARG0000004272643
GRB14 / growth factor receptor bound protein 14 / Q14449*ENSDARG0000006828032
raph1b / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b / RAPH1* / Q70E73* / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1*ENSDARG0000006173224
raph1a / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a / RAPH1* / Q70E73* / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1*ENSDARG0000000630123
apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta precursor protein binding family B member 1 interacting protein*ENSDARG0000001650520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015042  BPS (Between PH and SH2) domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035037  Grb10, SH2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005158 insulin receptor binding IEA


Pathways (from Reactome)
Pathway description
IRS activation
Signal attenuation
Insulin receptor signalling cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042723 gfra2a / GDNF family receptor alpha 2a / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000044015 gfra2b / GDNF family receptor alpha 2b / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000055305 ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...  / complex / reaction
 ENSDARG00000079849 nrtn / neurturin / P97463* / Q99748*  / complex / reaction
 ENSDARG00000074582 gfra4b / GDNF family receptor alpha 4b / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*  / complex / reaction
 ENSDARG00000087704 gfra3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSDARG00000011948 insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex / reaction
 ENSDARG00000035350 ins / O73727 / preproinsulin / Ins1* / IGF2* / Ins2* / F8WCM5* / P01326* / P01325* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / I...  / complex / reaction
 ENSDARG00000034610 insb / preproinsulin b / INS* / IGF2* / Ins1* / Ins2* / P01325* / F8WCM5* / P01326* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / ...  / complex / reaction
 ENSDARG00000071524 insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex / reaction
 ENSDARG00000039959 gdnfa / glial cell derived neurotrophic factor a / GDNF* / P39905* / P48540* / glial cell derived neurotrophic factor* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), tra...  / complex / reaction






 

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