ENSGALG00000013100


Gallus gallus

Features
Gene ID: ENSGALG00000013100
  
Biological name :GRB10
  
Synonyms : GRB10 / growth factor receptor bound protein 10
  
Possible biological names infered from orthology : Q13322 / Q60760
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 81116137
Gene end: 81255419
  
Corresponding Affymetrix probe sets: GgaAffx.8324.1.S1_s_at (Chicken Array)   GgaAffx.8324.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047411
Ensembl peptide - ENSGALP00000021356
NCBI entrez gene - 420948     See in Manteia.
RefSeq - XM_015282309
RefSeq - NM_001039282
RefSeq - XM_015282308
RefSeq Peptide - NP_001034371
swissprot - F1NT13
swissprot - A0A1D5P405
Ensembl - ENSGALG00000013100
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grb10aENSDARG00000002013Danio rerio
 grb10bENSDARG00000035308Danio rerio
 GRB10ENSG00000106070Homo sapiens
 Grb10ENSMUSG00000020176Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRB14 / growth factor receptor bound protein 14 / Q14449* / Q9JLM9*ENSGALG0000002070348
GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*ENSGALG0000003650048
APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*ENSGALG0000000757921
RAPH1* / Q70E73* / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1*ENSGALG0000003168810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015042  BPS (Between PH and SH2) domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0046325 negative regulation of glucose import IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005158 insulin receptor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
IRS activation
Signal attenuation
Insulin receptor signalling cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000006552 P67970 / INS-IGF2 / Insulin Insulin B chain Insulin A chain / INS* / Ins1* / Ins2* / F8WCM5* / P01308* / P01325* / P01326* / insulin* / INS-IGF2 readthrough* / Insulin-1 Insulin-1 B chain I...  / complex / reaction
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex / reaction
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / complex / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / complex / reaction
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / reaction / complex
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000040758 INSR / insulin receptor / P06213* / P15208* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex / reaction






 

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