ENSGALG00000038634


Gallus gallus

Features
Gene ID: ENSGALG00000038634
  
Biological name :KIT
  
Synonyms : KIT / Mast/stem cell growth factor receptor Kit / Q08156
  
Possible biological names infered from orthology : KIT proto-oncogene receptor tyrosine kinase / P05532 / P10721
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 65682458
Gene end: 65734704
  
Corresponding Affymetrix probe sets: Gga.606.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051217
NCBI entrez gene - 378783     See in Manteia.
RefSeq - NM_204361
RefSeq Peptide - NP_989692
swissprot - Q08156
Ensembl - ENSGALG00000038634
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kitaENSDARG00000043317Danio rerio
 kitbENSDARG00000056133Danio rerio
 KITENSG00000157404Homo sapiens
 KitENSMUSG00000005672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CSF1R / Gallus gallus colony stimulating factor 1 receptor (CSF1R), mRNA. / P07333* / P09581* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSGALG0000000572540
PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*ENSGALG0000001392934
PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *ENSGALG0000003061333
FLT4 / fms related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSGALG0000000580229
ENSGALG0000000764629
KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*ENSGALG0000001390729
FLT1 / vascular endothelial growth factor receptor 1 precursor / P17948* / fms related tyrosine kinase 1*ENSGALG0000001709129
FLT3 / fms related tyrosine kinase 3 / P36888*ENSGALG0000003572629
FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*ENSGALG0000001570824
FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSGALG0000000949523
FGFR4 / fibroblast growth factor receptor 4 / P22455*ENSGALG0000002854323
FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*ENSGALG0000003978623
RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*ENSGALG0000000255521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027263  Mast/stem cell growth factor receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0002318 myeloid progenitor cell differentiation IEA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IEA
 biological_processGO:0002327 immature B cell differentiation IEA
 biological_processGO:0002371 dendritic cell cytokine production IEA
 biological_processGO:0002551 mast cell chemotaxis IEA
 biological_processGO:0002573 myeloid leukocyte differentiation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006687 glycosphingolipid metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030318 melanocyte differentiation IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032762 mast cell cytokine production IEA
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0035234 ectopic germ cell programmed cell death IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035701 hematopoietic stem cell migration IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0038093 Fc receptor signaling pathway IEA
 biological_processGO:0038109 Kit signaling pathway IEA
 biological_processGO:0038162 erythropoietin-mediated signaling pathway IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043069 negative regulation of programmed cell death IEA
 biological_processGO:0043303 mast cell degranulation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048066 developmental pigmentation IEA
 biological_processGO:0048070 regulation of developmental pigmentation IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060374 mast cell differentiation IEA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:0097324 melanocyte migration IEA
 biological_processGO:0097326 melanocyte adhesion IEA
 biological_processGO:1905065 positive regulation of vascular smooth muscle cell differentiation IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042629 mast cell granule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005020 stem cell factor receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Signaling by SCF-KIT
Regulation of KIT signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008340 FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000014124 TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*  / complex / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / reaction / complex
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003282 STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*  / complex / reaction
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000014561 PTPN6 / tyrosine-protein phosphatase non-receptor type 6 / P29350* / P29351* / protein tyrosine phosphatase, non-receptor type 6*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000013100 GRB10 / growth factor receptor bound protein 10 / Q13322* / Q60760*  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000036500 GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000025950 PRKCA / protein kinase C alpha / P17252*  / complex / reaction
 ENSGALG00000042418 CHEK1 / Q8AYC9 / Serine/threonine-protein kinase Chk1 / O14757* / O35280* / checkpoint kinase 1*  / complex / reaction






 

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