ENSGALG00000014561


Gallus gallus

Features
Gene ID: ENSGALG00000014561
  
Biological name :PTPN6
  
Synonyms : PTPN6 / tyrosine-protein phosphatase non-receptor type 6
  
Possible biological names infered from orthology : P29350 / P29351 / protein tyrosine phosphatase, non-receptor type 6
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 77339324
Gene end: 77348760
  
Corresponding Affymetrix probe sets: Gga.9379.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023439
NCBI entrez gene - 427947     See in Manteia.
RefSeq - NM_001031484
RefSeq - XM_015293521
RefSeq Peptide - NP_001026655
swissprot - F1N843
Ensembl - ENSGALG00000014561
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn6ENSDARG00000089043Danio rerio
 PTPN6ENSG00000111679Homo sapiens
 Ptpn6ENSMUSG00000004266Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000003501759
PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*ENSGALG0000000482155
PTPRN / protein tyrosine phosphatase, receptor type N / Q16849*ENSGALG0000003381121
PTPRN2 / protein tyrosine phosphatase, receptor type N2 / P80560* / Q92932* / protein tyrosine phosphatase, receptor type, N polypeptide 2*ENSGALG0000003005420
PTPN5 / protein tyrosine phosphatase, non-receptor type 5 / P54829* / P54830* / Tyrosine-protein phosphatase non-receptor type 5 *ENSGALG0000000636817
PTPN7 / protein tyrosine phosphatase, non-receptor type 7 / P35236* / Q8BUM3* / Mus musculus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant 2, mRNA.*ENSGALG0000003609317
PTPRR* / Q15256* / Q62132* / protein tyrosine phosphatase, receptor type R*ENSGALG000000101488
PTPRR* / Q15256* / Q62132* / protein tyrosine phosphatase, receptor type R*ENSGALG000000408555


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000980  SH2 domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012152  Protein-tyrosine phosphatase, non-receptor type-6, -11
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0033277 abortive mitotic cell cycle IEA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0045577 regulation of B cell differentiation IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0050859 negative regulation of B cell receptor signaling pathway IEA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042105 alpha-beta T cell receptor complex IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005001 transmembrane receptor protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042169 SH2 domain binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0140031 phosphorylation-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of KIT signaling
PD-1 signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Neutrophil degranulation
Interferon gamma signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000019147 IL3RA* / P26951* / P26952* / P15509* / Q00941* / CSF2RA* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimul...  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / complex / reaction
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / reaction
 ENSGALG00000015062 IFNK* / IFNA6* / IFNA7* / IFNA8* / Ifna9* / Ifnab* / IFNW1* / IFNA2* / IFNA4* / IFNA1* / IFNA5* / Q9P0W0* / IFNA10* / Ifna11* / Ifna12* / IFNA13* / IFNA14* / Ifna15* / IFNA16* / IFNA17* / I...  / reaction
 ENSGALG00000014561 PTPN6 / tyrosine-protein phosphatase non-receptor type 6 / P29350* / P29351* / protein tyrosine phosphatase, non-receptor type 6*  / complex
 ENSGALG00000016693 CSF2RA / IL3RA* / P15509* / Q00941* / P26951* / P26952* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimula...  / complex / reaction
 ENSGALG00000030661 STAT2 / signal transducer and activator of transcription 2 / P52630*  / reaction
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / complex / reaction
 ENSGALG00000008267 IL5RA / interleukin 5 receptor subunit alpha / P21183* / Q01344*  / complex / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex






 

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