ENSGALG00000011031


Gallus gallus

Features
Gene ID: ENSGALG00000011031
  
Biological name :JAK1
  
Synonyms : JAK1 / tyrosine-protein kinase JAK1
  
Possible biological names infered from orthology : Janus kinase 1 / P23458
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 28300111
Gene end: 28351163
  
Corresponding Affymetrix probe sets: Gga.2435.1.S1_at (Chicken Array)   Gga.2435.1.S2_at (Chicken Array)   GgaAffx.11846.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017948
NCBI entrez gene - 395681     See in Manteia.
RefSeq - NM_204870
RefSeq - XM_015290965
RefSeq Peptide - NP_990201
swissprot - F1NMJ9
Ensembl - ENSGALG00000011031
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jak1ENSDARG00000020625Danio rerio
 JAK1ENSG00000162434Homo sapiens
 Jak1ENSMUSG00000028530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JAK2 / Janus kinase 2 / O60674*ENSGALG0000001502743
JAK3 / tyrosine-protein kinase JAK3 / P52333* / Janus kinase 3*ENSGALG0000003323430


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020776  Tyrosine-protein kinase, non-receptor Jak1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038110 interleukin-2-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK1 (ERK2) activation
Interleukin-7 signaling
Other interleukin signaling
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000892 IL10 / Q6A2H4 / Interleukin-10 / P18893* / P22301*  / complex / reaction
 ENSGALG00000002016 PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*  / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003282 STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*  / complex / reaction
 ENSGALG00000004221 Q80XZ4* / Q8N6P7* / IL22RA1* / interleukin 22 receptor subunit alpha 1*  / complex / reaction
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / complex / reaction
 ENSGALG00000007158 SOCS1 / suppressor of cytokine signaling 1 / O15524* / O35716*  / complex / reaction
 ENSGALG00000013869 IL20RA / interleukin 20 receptor subunit alpha / Q6PHB0* / Q9UHF4* / interleukin 20 receptor, alpha*  / complex
 ENSGALG00000009903 IFNG / P49708 / Interferon gamma / P01579* / P01580*  / complex / reaction
 ENSGALG00000014716 IL6ST / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex / reaction
 ENSGALG00000003747 OSMR / oncostatin M receptor / Q99650*  / complex / reaction
 ENSGALG00000009904 IL22 / interleukin 22 / Q9JJY8* / Q9JJY9* / Iltifb* / Q9GZX6* / Interleukin-22b *  / complex / reaction
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / complex / reaction
 ENSGALG00000010915 IL6 / Q90YI0 / Interleukin-6 / P05231* / P08505*  / complex / reaction
 ENSGALG00000015062 IFNK* / IFNA6* / IFNA7* / IFNA8* / Ifna9* / Ifnab* / IFNW1* / IFNA2* / IFNA4* / IFNA1* / IFNA5* / Q9P0W0* / IFNA10* / Ifna11* / Ifna12* / IFNA13* / IFNA14* / Ifna15* / IFNA16* / IFNA17* / I...  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000011844 IL21 / interleukin 21 / Q9ES17* / Q9HBE4*  / complex
 ENSGALG00000033141 B4ER10 / Interferon lambda-3 / IFNL1* / IFNL2* / IFNL3* / Q8IZJ0* / Q8IU54* / Q8IZI9* / Q4VK74* / Q8CGK6* / interferon lambda 2* / interferon lambda 1*  / complex / reaction
 ENSGALG00000033087 STAT4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSGALG00000030661 STAT2 / signal transducer and activator of transcription 2 / P52630*  / complex / reaction
 ENSGALG00000026207 CNTF / Q02011 / Ciliary neurotrophic factor / P26441* / P51642*  / complex / reaction
 ENSGALG00000033234 JAK3 / tyrosine-protein kinase JAK3 / P52333* / Janus kinase 3*  / complex
 ENSGALG00000014561 PTPN6 / tyrosine-protein phosphatase non-receptor type 6 / P29350* / P29351* / protein tyrosine phosphatase, non-receptor type 6*  / reaction
 ENSGALG00000013372 IL7R / interleukin 7 receptor / P16871* / P16872* / Interleukin-7 receptor subunit alpha *  / complex
 ENSGALG00000004231 K9JA28 / Interferon lambda receptor 1 / IFNLR1* / Q8CGK5* / Q8IU57*  / complex / reaction






 

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