ENSDARG00000020625


Danio rerio

Features
Gene ID: ENSDARG00000020625
  
Biological name :jak1
  
Synonyms : jak1 / Janus kinase 1
  
Possible biological names infered from orthology : P23458
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 31368071
Gene end: 31429161
  
Corresponding Affymetrix probe sets: Dr.275.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000037399
swissprot - F1R5C7
ZFIN ID - ZDB-GENE-980526-142
Ensembl - ENSDARG00000020625
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JAK1ENSGALG00000011031Gallus gallus
 JAK1ENSG00000162434Homo sapiens
 Jak1ENSMUSG00000028530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tyk2 / tyrosine kinase 2 / P29597*ENSDARG0000002032644
jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*ENSDARG0000001888239
jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*ENSDARG0000010480839
jak3 / Janus kinase 3 (a protein tyrosine kinase, leukocyte) / P52333* / Janus kinase 3*ENSDARG0000001025236


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020776  Tyrosine-protein kinase, non-receptor Jak1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
ISG15 antiviral mechanism
Interleukin-7 signaling
Interleukin-10 signaling
IL-6-type cytokine receptor ligand interactions
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001078 thymus thymus hypoplastic , abnormal
thymus cellularity , abnormal
thymus lacks parts or has fewer parts of type pro-T cell , abnormal
Show

 ZFA:0009350 pro-T cell pro-T cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex / reaction
 ENSDARG00000006368 crlf1b / cytokine receptor-like factor 1b / CRLF1* / O75462* / Q9JM58* / cytokine receptor like factor 1*  / complex / reaction
 ENSDARG00000052157 il12rb2 / interleukin 12 receptor, beta 2a / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000025428 socs3a / suppressor of cytokine signaling 3a / SOCS3* / O14543* / suppressor of cytokine signaling 3*  / complex / reaction
 ENSDARG00000010252 jak3 / Janus kinase 3 (a protein tyrosine kinase, leukocyte) / P52333* / Janus kinase 3*  / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSDARG00000078649 il21r.2 / interleukin 21 receptor, tandem duplicate 2 / IL21R* / Q9JHX3* / Q9HBE5* / interleukin 21 receptor*  / complex
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000028731 stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / complex
 ENSDARG00000068858 il2rga / interleukin 2 receptor, gamma a / IL2RG* / P34902* / P31785* / Gm20489* / AL590764.2* / interleukin 2 receptor subunit gamma* / Cytokine receptor common subunit gamma *  / complex
 ENSDARG00000078147 il10 / interleukin 10 / P18893* / P22301*  / complex
 ENSDARG00000075181 crfb16 / cytokine receptor family member B16 / IL20RB* / Q6UXL0* / interleukin 20 receptor subunit beta*  / complex
 ENSDARG00000075720 il2rb / interleukin 2 receptor, beta / P14784* / P16297* / interleukin 2 receptor subunit beta*  / complex / reaction
 ENSDARG00000078970 il7r / interleukin 7 receptor / P16871* / P16872* / Interleukin-7 receptor subunit alpha *  / complex
 ENSDARG00000020326 tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSDARG00000069961 il21r.1 / interleukin 21 receptor, tandem duplicate 1 / IL21R* / Q9JHX3* / Q9HBE5* / interleukin 21 receptor*  / complex
 ENSDARG00000053702 il2rgb / interleukin 2 receptor, gamma b / IL2RG* / P34902* / P31785* / Gm20489* / AL590764.2* / interleukin 2 receptor subunit gamma* / Cytokine receptor common subunit gamma *  / complex
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex / reaction
 ENSDARG00000099342 crfb15 / cytokine receptor family member B15 / Q08334* / IL10RB* / Gm21970* / interleukin 10 receptor subunit beta*  / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000104474 il6r / interleukin 6 receptor / P08887*  / complex / reaction
 ENSDARG00000026611 socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*  / complex / reaction
 ENSDARG00000032571 il20ra / interleukin 20 receptor, alpha / Q6PHB0* / Q9UHF4* / interleukin 20 receptor subunit alpha*  / complex
 ENSDARG00000024365 crlf1a / cytokine receptor-like factor 1a / CRLF1* / O75462* / Q9JM58* / cytokine receptor like factor 1*  / complex / reaction
 ENSDARG00000028661 cntfr / ciliary neurotrophic factor receptor / O88507* / P26992* / Ciliary neurotrophic factor receptor subunit alpha *  / complex / reaction
 ENSDARG00000076140 clcf1 / cardiotrophin-like cytokine factor 1 / Ctf2* / Q9UBD9* / P83714* / Q9QZM3* / Cardiotrophin-2 *  / complex / reaction






 

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