ENSDARG00000028731


Danio rerio

Features
Gene ID: ENSDARG00000028731
  
Biological name :stat4
  
Synonyms : signal transducer and activator of transcription 4 / stat4
  
Possible biological names infered from orthology : Q14765
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 41156287
Gene end: 41208343
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000147872
Ensembl peptide - ENSDARP00000157163
Ensembl peptide - ENSDARP00000096542
Ensembl peptide - ENSDARP00000115675
NCBI entrez gene - 368519     See in Manteia.
RefSeq - NM_001004510
RefSeq Peptide - NP_001004510
swissprot - B0S790
swissprot - F1R4W8
swissprot - Q8AW20
ZFIN ID - ZDB-GENE-030616-264
Ensembl - ENSDARG00000028731
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STAT4ENSGALG00000033087Gallus gallus
 STAT4ENSG00000138378Homo sapiens
 Stat4ENSMUSG00000062939Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
stat1a / signal transducer and activator of transcription 1a / STAT1* / P42224* / signal transducer and activator of transcription 1*ENSDARG0000000626648
stat3 / signal transducer and activator of transcription 3 (acute-phase response factor) / P40763* / P42227* / signal transducer and activator of transcription 3*ENSDARG0000002271248
stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*ENSDARG0000007618246
stat2 / signal transducer and activator of transcription 2 / P52630*ENSDARG0000003164741
stat5a / signal transducer and activator of transcription 5a / P42232* / P51692* / STAT5B* / P42229* / P42230* / signal transducer and activator of transcription 5B*ENSDARG0000001939229
stat5b / signal transducer and activator of transcription 5b / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*ENSDARG0000005558829
stat6 / signal transducer and activator of transcription 6, interleukin-4 induced / P42226* / P52633* / Signal transducer and transcription activator 6 * / signal transducer and activator o...ENSDARG0000001590226


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR029839  Signal transducer and activator of transcription 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-21 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex
 ENSDARG00000052157 il12rb2 / interleukin 12 receptor, beta 2a / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex
 ENSDARG00000010252 jak3 / Janus kinase 3 (a protein tyrosine kinase, leukocyte) / P52333* / Janus kinase 3*  / complex
 ENSDARG00000078649 il21r.2 / interleukin 21 receptor, tandem duplicate 2 / IL21R* / Q9JHX3* / Q9HBE5* / interleukin 21 receptor*  / complex
 ENSDARG00000028731 stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSDARG00000068858 il2rga / interleukin 2 receptor, gamma a / IL2RG* / P34902* / P31785* / Gm20489* / AL590764.2* / interleukin 2 receptor subunit gamma* / Cytokine receptor common subunit gamma *  / complex
 ENSDARG00000020326 tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSDARG00000069961 il21r.1 / interleukin 21 receptor, tandem duplicate 1 / IL21R* / Q9JHX3* / Q9HBE5* / interleukin 21 receptor*  / complex
 ENSDARG00000053702 il2rgb / interleukin 2 receptor, gamma b / IL2RG* / P34902* / P31785* / Gm20489* / AL590764.2* / interleukin 2 receptor subunit gamma* / Cytokine receptor common subunit gamma *  / complex
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex






 

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