ENSDARG00000076182


Danio rerio

Features
Gene ID: ENSDARG00000076182
  
Biological name :stat1b
  
Synonyms : signal transducer and activator of transcription 1b / stat1b
  
Possible biological names infered from orthology : P42224 / signal transducer and activator of transcription 1 / STAT1
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 41218967
Gene end: 41247197
  
Corresponding Affymetrix probe sets: Dr.21036.1.S1_at (Zebrafish Array)   Dr.26043.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000000280
Ensembl peptide - ENSDARP00000116740
Ensembl peptide - ENSDARP00000115509
NCBI entrez gene - 368481     See in Manteia.
RefSeq - XM_005167878
RefSeq - XM_009304879
RefSeq - NM_200091
RefSeq Peptide - NP_956385
swissprot - B0S791
swissprot - B0S789
ZFIN ID - ZDB-GENE-030616-23
Ensembl - ENSDARG00000076182
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STAT1ENSGALG00000007651Gallus gallus
 STAT1ENSG00000115415Homo sapiens
 Stat1ENSMUSG00000026104Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
stat1a / signal transducer and activator of transcription 1a / STAT1* / P42224* / signal transducer and activator of transcription 1*ENSDARG0000000626653
stat3 / signal transducer and activator of transcription 3 (acute-phase response factor) / P40763* / P42227* / signal transducer and activator of transcription 3*ENSDARG0000002271247
stat4 / signal transducer and activator of transcription 4 / Q14765*ENSDARG0000002873147
stat2 / signal transducer and activator of transcription 2 / P52630*ENSDARG0000003164738
stat5b / signal transducer and activator of transcription 5b / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*ENSDARG0000005558828
stat5a / signal transducer and activator of transcription 5a / P42232* / P51692* / STAT5B* / P42229* / P42230* / signal transducer and activator of transcription 5B*ENSDARG0000001939227
stat6 / signal transducer and activator of transcription 6, interleukin-4 induced / P42226* / P52633* / Signal transducer and transcription activator 6 * / signal transducer and activator o...ENSDARG0000001590226


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030097 hemopoiesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex / reaction
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000010252 jak3 / Janus kinase 3 (a protein tyrosine kinase, leukocyte) / P52333* / Janus kinase 3*  / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSDARG00000036094 pias1a / protein inhibitor of activated STAT, 1a / PIAS1* / O88907* / O75925* / protein inhibitor of activated STAT 1*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000062445 pias1b / protein inhibitor of activated STAT, 1b / PIAS1* / O88907* / O75925* / protein inhibitor of activated STAT 1*  / complex / reaction
 ENSDARG00000078649 il21r.2 / interleukin 21 receptor, tandem duplicate 2 / IL21R* / Q9JHX3* / Q9HBE5* / interleukin 21 receptor*  / complex
 ENSDARG00000028731 stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSDARG00000068858 il2rga / interleukin 2 receptor, gamma a / IL2RG* / P34902* / P31785* / Gm20489* / AL590764.2* / interleukin 2 receptor subunit gamma* / Cytokine receptor common subunit gamma *  / complex
 ENSDARG00000016457 irf9 / interferon regulatory factor 9 / Q00978* / Q61179*  / complex / reaction
 ENSDARG00000020326 tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSDARG00000069961 il21r.1 / interleukin 21 receptor, tandem duplicate 1 / IL21R* / Q9JHX3* / Q9HBE5* / interleukin 21 receptor*  / complex
 ENSDARG00000053702 il2rgb / interleukin 2 receptor, gamma b / IL2RG* / P34902* / P31785* / Gm20489* / AL590764.2* / interleukin 2 receptor subunit gamma* / Cytokine receptor common subunit gamma *  / complex
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex / reaction
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000104474 il6r / interleukin 6 receptor / P08887*  / complex / reaction
 ENSDARG00000043317 kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000052157 il12rb2 / interleukin 12 receptor, beta 2a / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*  / complex
 ENSDARG00000056133 kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000031647 stat2 / signal transducer and activator of transcription 2 / P52630*  / complex
 ENSDARG00000035986 ptpn2b / protein tyrosine phosphatase, non-receptor type 2, b / PTPN2* / P17706* / Q06180* / protein tyrosine phosphatase, non-receptor type 2* / Tyrosine-protein phosphatase non-receptor type 2 *  / reaction
 ENSDARG00000032571 il20ra / interleukin 20 receptor, alpha / Q6PHB0* / Q9UHF4* / interleukin 20 receptor subunit alpha*  / complex
 ENSDARG00000075181 crfb16 / cytokine receptor family member B16 / IL20RB* / Q6UXL0* / interleukin 20 receptor subunit beta*  / complex
 ENSDARG00000016481 ptpn2a / protein tyrosine phosphatase, non-receptor type 2, a / PTPN2* / P17706* / Q06180* / protein tyrosine phosphatase, non-receptor type 2* / Tyrosine-protein phosphatase non-receptor type 2 *  / reaction
 ENSDARG00000099342 crfb15 / cytokine receptor family member B15 / Q08334* / IL10RB* / Gm21970* / interleukin 10 receptor subunit beta*  / complex






 

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