ENSGALG00000007651


Gallus gallus

Features
Gene ID: ENSGALG00000007651
  
Biological name :STAT1
  
Synonyms : signal transducer and activator of transcription 1 / STAT1
  
Possible biological names infered from orthology : P42224
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 7920234
Gene end: 7940268
  
Corresponding Affymetrix probe sets: Gga.10555.1.A1_at (Chicken Array)   Gga.10555.1.S1_at (Chicken Array)   Gga.11597.1.S1_s_at (Chicken Array)   Gga.11597.2.S1_at (Chicken Array)   Gga.11597.2.S1_s_at (Chicken Array)   Gga.12662.1.S1_at (Chicken Array)   GgaAffx.22313.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000064550
Ensembl peptide - ENSGALP00000012376
Ensembl peptide - ENSGALP00000046362
NCBI entrez gene - 424044     See in Manteia.
RefSeq - XM_015289392
RefSeq - NM_001012914
RefSeq Peptide - NP_001012932
swissprot - A0A1L1S089
swissprot - Q5ZJK3
swissprot - F7BWA2
Ensembl - ENSGALG00000007651
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat1aENSDARG00000006266Danio rerio
 stat1bENSDARG00000076182Danio rerio
 STAT1ENSG00000115415Homo sapiens
 Stat1ENSMUSG00000026104Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAT4 / signal transducer and activator of transcription 4 / Q14765*ENSGALG0000003308754
STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*ENSGALG0000000326752
STAT2 / signal transducer and activator of transcription 2 / P52630*ENSGALG0000003066141
STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*ENSGALG0000000328226


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011992  EF-hand domain pair
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR022752  Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0010742 macrophage derived foam cell differentiation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0035456 response to interferon-beta IEA
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046725 negative regulation by virus of viral protein levels in host cell IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060337 type I interferon signaling pathway IEA
 biological_processGO:0061326 renal tubule development IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
Signaling by SCF-KIT
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002016 PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*  / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSGALG00000003282 STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*  / complex / reaction
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / complex / reaction
 ENSGALG00000007970 PIAS1 / E3 SUMO-protein ligase PIAS1 / O75925* / O88907* / protein inhibitor of activated STAT 1*  / complex / reaction
 ENSGALG00000013869 IL20RA / interleukin 20 receptor subunit alpha / Q6PHB0* / Q9UHF4* / interleukin 20 receptor, alpha*  / complex
 ENSGALG00000009903 IFNG / P49708 / Interferon gamma / P01579* / P01580*  / complex / reaction
 ENSGALG00000014716 IL6ST / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex / reaction
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / complex / reaction
 ENSGALG00000015062 IFNK* / IFNA6* / IFNA7* / IFNA8* / Ifna9* / Ifnab* / IFNW1* / IFNA2* / IFNA4* / IFNA1* / IFNA5* / Q9P0W0* / IFNA10* / Ifna11* / Ifna12* / IFNA13* / IFNA14* / Ifna15* / IFNA16* / IFNA17* / I...  / reaction / complex
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000011844 IL21 / interleukin 21 / Q9ES17* / Q9HBE4*  / complex
 ENSGALG00000033087 STAT4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSGALG00000030661 STAT2 / signal transducer and activator of transcription 2 / P52630*  / complex / reaction
 ENSGALG00000033234 JAK3 / tyrosine-protein kinase JAK3 / P52333* / Janus kinase 3*  / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000010915 IL6 / Q90YI0 / Interleukin-6 / P05231* / P08505*  / complex / reaction
 ENSGALG00000013867 PTPN2 / protein tyrosine phosphatase, non-receptor type 2 / P17706* / Q06180* / Tyrosine-protein phosphatase non-receptor type 2 *  / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction






 

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