ENSGALG00000003267


Gallus gallus

Features
Gene ID: ENSGALG00000003267
  
Biological name :STAT3
  
Synonyms : Q6DV79 / Signal transducer and activator of transcription 3 / STAT3
  
Possible biological names infered from orthology : P40763 / P42227
  
Species: Gallus gallus
  
Chr. number: 27
Strand: -1
Band:
Gene start: 5319501
Gene end: 5330786
  
Corresponding Affymetrix probe sets: Gga.11154.1.S1_s_at (Chicken Array)   Gga.8567.1.S1_at (Chicken Array)   GgaAffx.20135.1.S1_at (Chicken Array)   GgaAffx.20135.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044194
Ensembl peptide - ENSGALP00000005161
NCBI entrez gene - 420027     See in Manteia.
RefSeq - XM_015299601
RefSeq - NM_001030931
RefSeq - XM_015299598
RefSeq - XM_015299599
RefSeq - XM_015299600
RefSeq Peptide - NP_001026102
swissprot - Q6DV79
swissprot - A0A1D5NV21
Ensembl - ENSGALG00000003267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat3ENSDARG00000022712Danio rerio
 STAT3ENSG00000168610Homo sapiens
 Stat3ENSMUSG00000004040Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAT1 / signal transducer and activator of transcription 1 / P42224*ENSGALG0000000765150
STAT4 / signal transducer and activator of transcription 4 / Q14765*ENSGALG0000003308747
STAT2 / signal transducer and activator of transcription 2 / P52630*ENSGALG0000003066139
STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*ENSGALG0000000328227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011992  EF-hand domain pair
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0001754 eye photoreceptor cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0019953 sexual reproduction IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0033210 leptin-mediated signaling pathway IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0044320 cellular response to leptin stimulus IEA
 biological_processGO:0044321 response to leptin IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045820 negative regulation of glycolytic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048708 astrocyte differentiation IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060019 radial glial cell differentiation IEA
 biological_processGO:0060259 regulation of feeding behavior IEA
 biological_processGO:0060396 growth hormone receptor signaling pathway IEA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IEA
 biological_processGO:0072540 T-helper 17 cell lineage commitment IEA
 biological_processGO:0097009 energy homeostasis IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904685 positive regulation of metalloendopeptidase activity IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IEA
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 biological_processGO:2001223 negative regulation of neuron migration IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Downstream signal transduction
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003282 STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*  / complex / reaction
 ENSGALG00000000892 IL10 / Q6A2H4 / Interleukin-10 / P18893* / P22301*  / complex / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex
 ENSGALG00000004221 Q80XZ4* / Q8N6P7* / IL22RA1* / interleukin 22 receptor subunit alpha 1*  / complex
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / complex / reaction
 ENSGALG00000013869 IL20RA / interleukin 20 receptor subunit alpha / Q6PHB0* / Q9UHF4* / interleukin 20 receptor, alpha*  / complex
 ENSGALG00000009904 IL22 / interleukin 22 / Q9JJY8* / Q9JJY9* / Iltifb* / Q9GZX6* / Interleukin-22b *  / complex
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000011844 IL21 / interleukin 21 / Q9ES17* / Q9HBE4*  / complex
 ENSGALG00000013372 IL7R / interleukin 7 receptor / P16871* / P16872* / Interleukin-7 receptor subunit alpha *  / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000033087 STAT4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSGALG00000033234 JAK3 / tyrosine-protein kinase JAK3 / P52333* / Janus kinase 3*  / complex / reaction
 ENSGALG00000045814 CRLF2 / cytokine receptor like factor 2 / Q9HC73* / cytokine receptor-like factor 2 isoform 1 *  / complex
 ENSGALG00000014716 IL6ST / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex / reaction
 ENSGALG00000010915 IL6 / Q90YI0 / Interleukin-6 / P05231* / P08505*  / complex / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction






 

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