ENSGALG00000011844


Gallus gallus

Features
Gene ID: ENSGALG00000011844
  
Biological name :IL21
  
Synonyms : IL21 / interleukin 21
  
Possible biological names infered from orthology : Q9ES17 / Q9HBE4
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 54036328
Gene end: 54041083
  
Corresponding Affymetrix probe sets: GgaAffx.7525.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019301
NCBI entrez gene - 554218     See in Manteia.
RefSeq - NM_001024835
RefSeq Peptide - NP_001020006
swissprot - Q58IU6
Ensembl - ENSGALG00000011844
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL21ENSG00000138684Homo sapiens
 Il21ENSMUSG00000027718Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003443  Interleukin-15/Interleukin-21 family
 IPR009079  Four-helical cytokine-like, core
 IPR028151  Interleukin-21


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0032740 positive regulation of interleukin-17 production IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0048469 cell maturation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005134 interleukin-2 receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-21 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / complex
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / complex
 ENSGALG00000033234 JAK3 / tyrosine-protein kinase JAK3 / P52333* / Janus kinase 3*  / complex
 ENSGALG00000033087 STAT4 / signal transducer and activator of transcription 4 / Q14765*  / complex






 

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