ENSDARG00000020326


Danio rerio

Features
Gene ID: ENSDARG00000020326
  
Biological name :tyk2
  
Synonyms : tyk2 / tyrosine kinase 2
  
Possible biological names infered from orthology : P29597
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 46479705
Gene end: 46555542
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124187
Ensembl peptide - ENSDARP00000152966
NCBI entrez gene - 100536675     See in Manteia.
RefSeq - XM_003198153
RefSeq - XM_005164236
RefSeq - XM_009299743
swissprot - F8W4H3
ZFIN ID - ZDB-GENE-071116-4
Ensembl - ENSDARG00000020326
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TYK2ENSG00000105397Homo sapiens
 Tyk2ENSMUSG00000032175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
jak1 / Janus kinase 1 / P23458*ENSDARG0000002062544
jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*ENSDARG0000001888237
jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*ENSDARG0000010480837
jak3 / Janus kinase 3 (a protein tyrosine kinase, leukocyte) / P52333* / Janus kinase 3*ENSDARG0000001025236


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016045  Tyrosine-protein kinase, non-receptor, TYK2, N-terminal
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex
 ENSDARG00000052157 il12rb2 / interleukin 12 receptor, beta 2a / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex
 ENSDARG00000028731 stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSDARG00000078147 il10 / interleukin 10 / P18893* / P22301*  / complex
 ENSDARG00000078042 il10rb / interleukin 10 receptor, beta / P33896* / IFNAR1* / P17181* / Interferon alpha/beta receptor 1 * / interferon alpha and beta receptor subunit 1*  / complex
 ENSDARG00000032571 il20ra / interleukin 20 receptor, alpha / Q6PHB0* / Q9UHF4* / interleukin 20 receptor subunit alpha*  / complex
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000020326 tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex
 ENSDARG00000099342 crfb15 / cytokine receptor family member B15 / Q08334* / IL10RB* / Gm21970* / interleukin 10 receptor subunit beta*  / complex / reaction
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex






 

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